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Literature summary extracted from

  • Shin, E.S.; Cho, S.Y.; Lee, E.H.; Lee, S.J.; Chang, I.S.; Lee, T.R.
    Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine (2006), Eur. J. Nutr., 45, 159-164.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.21 daidzein
-
 Mus musculus
2.3.1.21 daidzein activates 5.5fold, induces the enzyme expression Homo sapiens
2.3.1.21 genistein
-
 Mus musculus
2.3.1.21 genistein activates 3fold alone, and about 6fold in concert with L-carnitine, induces the enzyme expression Homo sapiens
2.3.1.21 L-carnitine
-
 Mus musculus
2.3.1.21 L-carnitine activates 3fold alone, and about 6fold in concert with genistein, induces the enzyme expression Homo sapiens
2.3.1.21 additional information clofibrate induces the enzyme expression in transfected Huh-7 cells Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.21 quantitative expression analysis Mus musculus
2.3.1.21 quantitative expression analysis, expression in Huh-7 cells, treatment with clofibrate induces the enzyme expression Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Mus musculus 5739
-
2.3.1.21 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine Mus musculus regulation, mechanism, overview CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine Homo sapiens regulation, mechanism, overview CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine Mus musculus C57/BL6J regulation, mechanism, overview CoA + L-palmitoylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
-
-
2.3.1.21 Mus musculus
-
 C57BL/6J mice
-
2.3.1.21 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.21 liver CPT1A Mus musculus
-
2.3.1.21 liver CPT1A Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 additional information
-
 quantitative expression analysis Mus musculus
2.3.1.21 additional information
-
 quantitative expression analysis Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Mus musculus CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine regulation, mechanism, overview Mus musculus CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine regulation, mechanism, overview Homo sapiens CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Mus musculus C57/BL6J CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine regulation, mechanism, overview Mus musculus C57/BL6J CoA + L-palmitoylcarnitine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyl transferase 1A
-
 Mus musculus
2.3.1.21 carnitine palmitoyl transferase 1A
-
 Homo sapiens
2.3.1.21 CPT1A
-
 Mus musculus
2.3.1.21 CPT1A
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.21 37
-
 assay at Mus musculus
2.3.1.21 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.21 8
-
 assay at Mus musculus
2.3.1.21 8
-
 assay at Homo sapiens