EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.122 | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-methyl ethyl butylphosphonate | IC50: 0.010 mM | Mycobacterium avium | |
2.3.1.122 | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-methyl ethyl tetradecylphosphonate | IC50: 0.0410 mM | Mycobacterium avium | |
2.3.1.122 | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl ethyl heptylphosphonate | IC50: 0.0013 mM | Mycobacterium avium | |
2.3.1.122 | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl ethyl nonylphosphonate | IC50: 0.0871 mM | Mycobacterium avium | |
2.3.1.122 | 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-ethyl ethyl butylphosphonate | IC50: 0.0507 mM | Mycobacterium avium | |
2.3.1.122 | 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-ethyl ethyl nonylphosphonate | IC50: 0.0257 mM | Mycobacterium avium | |
2.3.1.122 | 2-phenylethanol | - |
Mycobacterium avium | |
2.3.1.122 | 3,4,5-trimethoxybenzylphosphonate | IC50: 0.102 mM | Mycobacterium avium | |
2.3.1.122 | 4-(phthalimido)butanol | - |
Mycobacterium avium | |
2.3.1.122 | ethyl 3-phenoxybenzyl butylphosphonate | IC50: 0.002 mM | Mycobacterium avium | |
2.3.1.122 | ethyl 3-phenoxybenzyl heptylphosphonate | IC50: 0.021 mM | Mycobacterium avium | |
2.3.1.122 | ethyl 3-phenoxybenzyl hexylphosphonate | IC50: 0.0426 mM | Mycobacterium avium | |
2.3.1.122 | ethyl 3-phenoxybenzyl nonylphosphonate | IC50: 0.0148 mM | Mycobacterium avium | |
2.3.1.122 | ethyl 3-phenoxybenzyl tetradecylphosphonate | IC50: 0.862 mM | Mycobacterium avium | |
2.3.1.122 | ethyl hydrogen 2-phenylethyl phosphonate | IC50: 0.225 mM | Mycobacterium avium | |
2.3.1.122 | ethyl hydrogen 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butylphosphonate | IC50: 0.110 mM | Mycobacterium avium | |
2.3.1.122 | ethyl hydrogen butylphosphonate | IC50: 0.431 mM | Mycobacterium avium | |
2.3.1.122 | ethyl hydrogen heptylphosphonate | IC50: 0.0011 mM | Mycobacterium avium | |
2.3.1.122 | ethyl hydrogen hexylphosphonate | IC50: 0.0036 mM | Mycobacterium avium | |
2.3.1.122 | ethyl hydrogen nonylphosphonate | IC50: 0.471 mM | Mycobacterium avium | |
2.3.1.122 | additional information | design of mechanism-based inhibitors, growth inhibition assay, molecular docking, overview | Mycobacterium avium | |
2.3.1.122 | N-(omega-hydroxyalky)phthalimide | - |
Mycobacterium avium |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.122 | alpha,alpha-trehalose 6-mycolate | Mycobacterium avium | - |
alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.122 | Mycobacterium avium | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.1.122 | 2 alpha,alpha-trehalose 6-mycolate = alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate | reaction mechanism via enzyme complexed with the tetrahedral transition state and mycolic acid covalently attached to the enzyme, the catalytic triad is formed by Ser124, Glu228 and His260 | Mycobacterium avium |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.122 | alpha,alpha-trehalose 6-mycolate | - |
Mycobacterium avium | alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.122 | ag85C | - |
Mycobacterium avium |
2.3.1.122 | antigen 85C | - |
Mycobacterium avium |
2.3.1.122 | mycolyltransferase | - |
Mycobacterium avium |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.122 | 37 | - |
assay at | Mycobacterium avium |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.122 | 7.5 | - |
assay at | Mycobacterium avium |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.122 | 0.0011 | - |
IC50: 0.0011 mM | Mycobacterium avium | ethyl hydrogen heptylphosphonate | |
2.3.1.122 | 0.0013 | - |
IC50: 0.0013 mM | Mycobacterium avium | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl ethyl heptylphosphonate | |
2.3.1.122 | 0.002 | - |
IC50: 0.002 mM | Mycobacterium avium | ethyl 3-phenoxybenzyl butylphosphonate | |
2.3.1.122 | 0.0036 | - |
IC50: 0.0036 mM | Mycobacterium avium | ethyl hydrogen hexylphosphonate | |
2.3.1.122 | 0.01 | - |
IC50: 0.010 mM | Mycobacterium avium | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-methyl ethyl butylphosphonate | |
2.3.1.122 | 0.0148 | - |
IC50: 0.0148 mM | Mycobacterium avium | ethyl 3-phenoxybenzyl nonylphosphonate | |
2.3.1.122 | 0.021 | - |
IC50: 0.021 mM | Mycobacterium avium | ethyl 3-phenoxybenzyl heptylphosphonate | |
2.3.1.122 | 0.0257 | - |
IC50: 0.0257 mM | Mycobacterium avium | 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-ethyl ethyl nonylphosphonate | |
2.3.1.122 | 0.041 | - |
IC50: 0.0410 mM | Mycobacterium avium | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-methyl ethyl tetradecylphosphonate | |
2.3.1.122 | 0.0426 | - |
IC50: 0.0426 mM | Mycobacterium avium | ethyl 3-phenoxybenzyl hexylphosphonate | |
2.3.1.122 | 0.0507 | - |
IC50: 0.0507 mM | Mycobacterium avium | 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-ethyl ethyl butylphosphonate | |
2.3.1.122 | 0.0871 | - |
IC50: 0.0871 mM | Mycobacterium avium | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl ethyl nonylphosphonate | |
2.3.1.122 | 0.102 | - |
IC50: 0.102 mM | Mycobacterium avium | 3,4,5-trimethoxybenzylphosphonate | |
2.3.1.122 | 0.11 | - |
IC50: 0.110 mM | Mycobacterium avium | ethyl hydrogen 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butylphosphonate | |
2.3.1.122 | 0.225 | - |
IC50: 0.225 mM | Mycobacterium avium | ethyl hydrogen 2-phenylethyl phosphonate | |
2.3.1.122 | 0.431 | - |
IC50: 0.431 mM | Mycobacterium avium | ethyl hydrogen butylphosphonate | |
2.3.1.122 | 0.471 | - |
IC50: 0.471 mM | Mycobacterium avium | ethyl hydrogen nonylphosphonate | |
2.3.1.122 | 0.862 | - |
IC50: 0.862 mM | Mycobacterium avium | ethyl 3-phenoxybenzyl tetradecylphosphonate |