Literature summary extracted from

Doell, F.; Pfeilschifter, J.; Huwiler, A.
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration (2007), Endocr. Relat. Cancer, 14, 325-335.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.91	additional information	not activated by prolactin	Homo sapiens
2.7.1.91	prolactin	-	Homo sapiens

Application

EC Number	Application	Comment	Organism
2.7.1.91	medicine	anti-tumor therapy	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.91	Homo sapiens	Q9NRA0	-	-
2.7.1.91	Homo sapiens	Q9NYA1	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.91	MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.91	ATP + sphingosine	-	Homo sapiens	ADP + sphingosine 1-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.1.91	SK-1	-	Homo sapiens
2.7.1.91	SK-2	-	Homo sapiens
2.7.1.91	sphinganine kinase	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.1.91	ATP	-	Homo sapiens

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Release 2023.1 (January 2023)