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Literature summary extracted from

  • Iqbal, J.; Burbiel, J.C.; Mueller, C.E.
    Development of off-line and on-line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates (2006), Electrophoresis, 27, 2505-2517.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 (2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol
-
 Bos taurus
2.7.1.20 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine
-
 Bos taurus
2.7.1.20 5-iodotubercidin
-
 Bos taurus
2.7.1.20 additional information development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.20
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.20 additional information
-
 development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + 2-(4-benzylpiperazin-1-yl)adenosine 3% of the activity with adenosine Bos taurus ADP + 2-(4-benzylpiperazin-1-yl)adenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + 2-(pyrrolidin-1-yl)adenosine 53% of the activity with adenosine Bos taurus ADP + 2-(pyrrolidin-1-yl)adenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + 2-benzylaminoadenosine 4% of the activity with adenosine Bos taurus ADP + 2-benzylaminoadenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + 2-cyclohexylaminoadenosine 3% of the activity with adenosine Bos taurus ADP + 2-cyclohexylaminoadenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + 2-ethylaminoadenosine 3% of the activity with adenosine Bos taurus ADP + 2-ethylaminoadenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + 2-isopropylamino-N6-isopropyladenosine 81% of the activity with adenosine Bos taurus ADP + 2-isopropylamino-N6-isopropyladenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + 2-isopropylaminoadenosine 4% of the activity with adenosine Bos taurus ADP + 2-isopropylaminoadenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + adenosine
-
 Bos taurus ADP + AMP
-
 ?
2.7.1.20 additional information development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.20 additional information
-
 additional information development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus
2.7.1.20 0.00000006
-
 (2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol Ki-value determined by on-line capillary electrophoresis Bos taurus
2.7.1.20 0.00000009
-
 (2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol Ki-value determined by off-line capillary electrophoresis Bos taurus
2.7.1.20 0.0000014
-
 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine Ki-value determined by off-line capillary electrophoresis Bos taurus
2.7.1.20 0.0000017
-
 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine Ki-value determined by on-line capillary electrophoresis Bos taurus
2.7.1.20 0.0000306
-
 5-iodotubercidin
-
 Bos taurus