Literature summary extracted from

Charlton-Menys, V.; Durrington, P.N.
Squalene synthase inhibitors: clinical pharmacology and cholesterol-lowering potential (2007), Drugs, 67, 11-16.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.5.1.21	BMS-187745	-	Homo sapiens
2.5.1.21	BMS-188494	-	Homo sapiens
2.5.1.21	EP2302	-	Homo sapiens
2.5.1.21	ER-27856	-	Homo sapiens
2.5.1.21	simvastatin	-	Homo sapiens
2.5.1.21	TAK-475	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.21	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.5.1.21	Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.21	farnesyl diphosphate + NAD(P)H + H+	-	Homo sapiens	squalene + diphosphate + NAD(P)+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.5.1.21	NAD(P)H	-	Homo sapiens

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Release 2023.1 (January 2023)