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Literature summary extracted from

  • Miyata, M.; Matsuda, Y.; Tsuchiya, H.; Kitada, H.; Akase, T.; Shimada, M.; Nagata, K.; Gonzalez, F.J.; Yamazoe, Y.
    Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase (2006), Drug Metab. Pharmacokinet., 21, 315-323.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.15 additional information lithocholic acid induces SULT2A in wild-type and farnesoid X receptor-null mice, chenodeoxycholic acid induces the enzyme only in farnesoid X receptor-null mice, not in wild-type mice, overview Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15 expression of His-tagged SULT2A in Escherichia coli Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.15 additional information expression of SULT1A1 is reduced in Hep-G2 cells by farnesoid X receptor FXR agonists chenodeoxycholic acid and GW4064, chenodeoxycholic acid also decreases SULT2A expression in wild-type mice Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Mus musculus
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 additional information Mus musculus the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Mus musculus
-
 wild-type and farnesoid X receptor-null mice
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.15 recombinant His-tagged SULT2A1 from Escherichia coli by nickel affinity chromatography, expression analysis Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.15 liver SULT2A levels in liver are 8fold higher in farnesoid X receptor-null micethan in wild-type mice Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Mus musculus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 additional information the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 hydroxysteroid sulfotransferase
-
 Mus musculus
2.8.2.15 More cf. EC 2.8.2.14, bile salt sulfotransferase 2, SULT2A2 Mus musculus
2.8.2.15 SULT2A1
-
 Mus musculus