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Literature summary extracted from

  • Kaji, H.; Kume, T.
    Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A) (2005), Drug Metab. Pharmacokinet., 20, 212-218.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
 Homo sapiens
2.4.1.17 bilirubin 0.1 mM, 95.7% inhibition. 0.003 mM, 64.7% inhibition; 0.1 mM, very weak inhibition; very weak inhibition Homo sapiens
2.4.1.17 diclofenac 0.01 mM, 40.6% inhibition. 0.03 mM, 67% inhibition; very weak inhibition; weak; weak Homo sapiens
2.4.1.17 genistein 0.003 mM, 25.4% inhibition. 0.03 mM, 79.5% inhibition; 0.003 mM, 38.8% inhibition. 0.03 mM, 97.6% inhibition; weak; weak Homo sapiens
2.4.1.17 propofol 0.03 mM, weak inhibition; 0.1 mM, weak; weak inhibition at 0.03 mM, moderate inhibition at 0.1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.0119
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid Hill equation Homo sapiens
2.4.1.17 0.0456
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid Hill equation Homo sapiens
2.4.1.17 0.138
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
 Homo sapiens
2.4.1.17 0.293
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid Hill equation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate Homo sapiens glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine ?
-
 ?
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate Homo sapiens glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans ?
-
 ?
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate Homo sapiens glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656 recombinant
-
2.4.1.17 Homo sapiens P16662 recombinant
-
2.4.1.17 Homo sapiens P22309 recombinant
-
2.4.1.17 Homo sapiens P35503 recombinant
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 intestine
-
 Homo sapiens
-
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine Homo sapiens ?
-
 ?
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans Homo sapiens ?
-
 ?
2.4.1.17 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A1
-
 Homo sapiens
2.4.1.17 UGT1A3
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 1.56
-
 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
 Homo sapiens