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Literature summary extracted from

  • Bowalgaha, K.; Elliot, D.J.; Mackenzie, P.I.; Knights, K.M.; Miners, J.O.
    The glucuronidation of DELTA4-3-keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7 (2007), Drug Metab. Dispos., 35, 363-370.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.003
-
 6alpha-hydroxyprogesterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.0038
-
 testosterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.0057
-
 testosterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.0069
-
 11alpha-hydroxyprogesterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.019
-
 Mn2+[side2] 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.055
-
 6alpha-hydroxyprogesterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.073
-
 16alpha-hydroxyprogesterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.093
-
 11alpha-hydroxyprogesterone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.211
-
 16alpha-hydroxyprogesterone 37°C, pH 7.4 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 11alpha-hydroxyprogesterone + UDP-glucuronate Homo sapiens
-
 UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate Homo sapiens UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation ?
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate Homo sapiens
-
 UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate Homo sapiens UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
-
 ?
2.4.1.17 21-hydroxyprogesterone + UDP-glucuronate Homo sapiens
-
 UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
-
 ?
2.4.1.17 6alpha-hydroxyprogesterone + UDP-glucuronate Homo sapiens
-
 UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
-
 ?
2.4.1.17 testosterone + UDP-glucuronate Homo sapiens UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation UDP + testosterone beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656
-
-
2.4.1.17 Homo sapiens O75795
-
-
2.4.1.17 Homo sapiens P16662
-
-
2.4.1.17 Homo sapiens P22310
-
-
2.4.1.17 Homo sapiens P54855
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 11alpha-hydroxyprogesterone + UDP-glucuronate
-
 Homo sapiens UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation Homo sapiens ?
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate
-
 Homo sapiens UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
-
 ?
2.4.1.17 16alpha-hydroxyprogesterone + UDP-glucuronate UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation Homo sapiens UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
-
 ?
2.4.1.17 21-hydroxyprogesterone + UDP-glucuronate
-
 Homo sapiens UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
-
 ?
2.4.1.17 6alpha-hydroxyprogesterone + UDP-glucuronate
-
 Homo sapiens UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
-
 ?
2.4.1.17 testosterone + UDP-glucuronate
-
 Homo sapiens UDP + testosterone beta-D-glucuronoside
-
 ?
2.4.1.17 testosterone + UDP-glucuronate UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation Homo sapiens UDP + testosterone beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A4
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens
2.4.1.17 UGT2B15
-
 Homo sapiens
2.4.1.17 UGT2B17
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens