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Literature summary extracted from

  • Tallman, M.N.; Ritter, J.K.; Smith, P.C.
    Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms (2005), Drug Metab. Dispos., 33, 977-983.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656 recombinant
-
2.4.1.17 Homo sapiens P22309
-
-
2.4.1.17 Homo sapiens Q9HAW7 recombinant
-
2.4.1.17 Homo sapiens Q9HAW9 recombinant
-
2.4.1.17 Rattus norvegicus Q64550 recombinant
-
2.4.1.17 Rattus norvegicus Q64633 recombinant
-
2.4.1.17 Rattus norvegicus Q64634 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
-
 Homo sapiens UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
-
 ?
2.4.1.17 7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
-
 Rattus norvegicus UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
-
 ?
2.4.1.17 7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
-
 Homo sapiens UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
-
 ?
2.4.1.17 7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
-
 Rattus norvegicus UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A
-
 Homo sapiens
2.4.1.17 UGT1A1
-
 Rattus norvegicus
2.4.1.17 UGT1A7
-
 Homo sapiens
2.4.1.17 UGT1A7
-
 Rattus norvegicus
2.4.1.17 UGT1A8
-
 Homo sapiens
2.4.1.17 UGT1A8
-
 Rattus norvegicus
2.4.1.17 UGT1A9
-
 Homo sapiens