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Literature summary extracted from

  • Costantini, S.; Woodbine, L.; Andreoli, L.; Jeggo, P.A.; Vindigni, A.
    Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK (2007), DNA Repair, 6, 712-722.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.5.1.1 nucleus
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Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens DNA non-homologous end-joining is a major mechanism for repairing DNA double-stranded breaks in mammalian cells. Key components of the DNA non-homologous end-joining machinery are the Ku heterodimer and the DNA ligase IC/Xrcc4 complex. Ku interacts with DNA ligase IV via its tandem BRCT domain. This interaction is enhanced in the presence of Xrcc4 and dsDNA. Ku nedds to be in its heterodimeric form to bind DNA ligase IV. Altough the interaction between Ku and DNA ligase IV/Xrcc4 occurs in the absence of DNA-PKc, the presence of the catalytic subunit of DNA-PK kinase enhances complex formation AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m DNA non-homologous end-joining is a major mechanism for repairing DNA double-stranded breaks in mammalian cells. Key components of the DNA non-homologous end-joining machinery are the Ku heterodimer and the DNA ligase IC/Xrcc4 complex. Ku interacts with DNA ligase IV via its tandem BRCT domain. This interaction is enhanced in the presence of Xrcc4 and dsDNA. Ku nedds to be in its heterodimeric form to bind DNA ligase IV. Altough the interaction between Ku and DNA ligase IV/Xrcc4 occurs in the absence of DNA-PKc, the presence of the catalytic subunit of DNA-PK kinase enhances complex formation Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
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Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase IV
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Homo sapiens