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Literature summary extracted from

  • Petermann, E.; Keil, C.; Oei, S.L.
    Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER (2006), DNA Repair, 5, 544-555.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens damaged DNA bases are repaired by base excision repair which can proceed via two pathways: short patch and long patch base excision repair. Inhibition of long patch base excision repair is mediated by the ligation activity of Lig III. Lowering the levels of XRCC1 and Lig III in HeLa cells decreases cellular repair capacity, but substantially increases Pol beta-dependent strand displacement DNA synthesis AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m damaged DNA bases are repaired by base excision repair which can proceed via two pathways: short patch and long patch base excision repair. Inhibition of long patch base excision repair is mediated by the ligation activity of Lig III. Lowering the levels of XRCC1 and Lig III in HeLa cells decreases cellular repair capacity, but substantially increases Pol beta-dependent strand displacement DNA synthesis Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
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Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase III
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Homo sapiens
6.5.1.1 Lig III
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Homo sapiens