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Literature summary extracted from

  • Biddinger, S.B.; Miyazaki, M.; Boucher, J.; Ntambi, J.M.; Kahn, C.R.
    Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c (2006), Diabetes, 55, 2032-2041.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Mus musculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.1 additional information
-
 SCD protein undetectable in 24 microg/day leptin-treated ob/ob mice with or without exogenous insulin treatment Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Mus musculus
-
 ob/ob mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver 24 microg/day leptin treatment for 4 days with or without exogenous insulin treatment of ob/ob mice suppresses mRNA, SCD protein undetectable in leptin-treated ob/ob mice with or without exogenous insulin treatment Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.1 additional information
-
 10fold suppression in 24 microg/day leptin-treated ob/ob mice with or without exogenous insulin treatment Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + AH2 + O2
-
 Mus musculus oleoyl-CoA + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
 Mus musculus