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Literature summary extracted from

  • Biddinger, S.B.; Almind, K.; Miyazaki, M.; Kokkotou, E.; Ntambi, J.M.; Kahn, C.R.
    Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome (2005), Diabetes, 54, 1314-1323.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome from liver Mus musculus
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Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Mus musculus
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 C57Bl/B6 and 129S6/SvEvTac mice
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver
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 Mus musculus
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1.14.19.1 skeletal muscle C57Bl/B6 mice under low-fat diet have 3 to 4 times more SCD1 transcript than 129S6/SvEvTac mice under low-fat diet, mRNA increased 3fold by high-fat feeding of 129S6/SvEvTac mice and 1.5fold by high-fat feeding of C57Bl/B6 mice Mus musculus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.1 0.0002
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 129S6/SvEvTac mice under low-fat diet, liver microsomes, stearoyl-CoA as substrate Mus musculus
1.14.19.1 0.0004
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 129S6/SvEvTac mice under high-fat diet, liver microsomes, stearoyl-CoA as substrate Mus musculus
1.14.19.1 0.0011
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 C57Bl/B6 mice under low-fat diet, liver microsomes, stearoyl-CoA as substrate Mus musculus
1.14.19.1 0.0016
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 C57Bl/B6 mice under high-fat diet, liver microsomes, stearoyl-CoA as substrate Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + NADH + O2
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 Mus musculus oleoyl-CoA + NAD+ + H2O
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
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 Mus musculus