EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.15.4 | gene CYP11B2, located on chromosome 8q22, DAN and amino acid sequence determination, determination and analysis of the -344 polymorphism | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.15.4 | additional information | the -344 T/C promoter polymorphism of CYP11B2 is involved in diabetic nephropathy, analysis of allele and genotype distributions and frequencies of the CYP11B2 -344T/C polymorphism | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.4 | 18-hydroxycorticosterone + reduced ferredoxin + O2 | Homo sapiens | aldosterone is one of the main effectors of the reninangiotensinaldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure | aldosterone + ferredoxin + H2O | - |
? | |
1.14.15.4 | additional information | Homo sapiens | -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.15.4 | Homo sapiens | - |
adult Danish Caucasian Type 1 diabetic patients with diabetic nephropathy | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.4 | 18-hydroxycorticosterone + reduced ferredoxin + O2 | - |
Homo sapiens | aldosterone + ferredoxin + H2O | - |
? | |
1.14.15.4 | 18-hydroxycorticosterone + reduced ferredoxin + O2 | aldosterone is one of the main effectors of the reninangiotensinaldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure | Homo sapiens | aldosterone + ferredoxin + H2O | - |
? | |
1.14.15.4 | additional information | -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.15.4 | Aldosterone synthase | - |
Homo sapiens |
1.14.15.4 | CYP11B2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.4 | Ferredoxin | - |
Homo sapiens |