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Literature summary extracted from

  • Godfrey, E.W.; Longacher, M.; Neiswender, H.; Schwarte, R.C.; Browning, D.D.
    Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction (2007), Dev. Biol., 307, 195-201.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 8-bromo-cyclic GMP
-
 Bos taurus
2.7.11.12 cGMP
-
 Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.12 expression of PKGIalpha in transgenic Xenopus laevis embryos Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.12 additional information overexpression in Xenopus laevis of either guanylate cyclase or PKG in embryos increases acetylcholine receptor aggregate area by 60–170%, whereas expression of a dominant negative form of guanylate cyclase inhibits endogenous aggregation by 50%, overview Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 Rp-8-pCPT-cGMPS
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.12 neuromuscular junction
-
 Bos taurus 31594
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 additional information Bos taurus guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the postsynaptic differentiation of developing neuromuscular junctions, molecular mechanism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 skeletal muscle cell embryonic Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 additional information guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the postsynaptic differentiation of developing neuromuscular junctions, molecular mechanism Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 cyclic GMP-dependent protein kinase
-
 Bos taurus
2.7.11.12 PKG
-
 Bos taurus