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Literature summary extracted from

  • Galietta, L.J.; Moran, O.
    Identification of CFTR activators and inhibitors: chance or design? (2004), Curr. Opin. Pharmacol., 4, 497-503.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.6 1,10-phenanthroline
-
 Homo sapiens
5.6.1.6 benzimidazolone compounds
-
 Homo sapiens
5.6.1.6 benzoquinolizinium compounds
-
 Homo sapiens
5.6.1.6 flavonoid
-
 Homo sapiens
5.6.1.6 fluorescein derivative
-
 Homo sapiens
5.6.1.6 xanthine
-
 Homo sapiens

Application

EC Number Application Comment Organism
5.6.1.6 medicine CFTR is a phamacological target for activators and inhibitors, acivators are useful for phamacotherapy of cystic fibrosis, conversely, inhibitors are useful to treat secretory diarrhoea caused by enterotoxins Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.6 5-nitro-2(3-phenylpropylamino)benzoate
-
 Homo sapiens
5.6.1.6 CFTRinh-172 possibly inhibits CFTR currents by alteration of gating mechanisms Homo sapiens
5.6.1.6 diphenylamine-2-carboxylate
-
 Homo sapiens
5.6.1.6 glibenclamide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.6 epithelial cell airway Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Homo sapiens
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens