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Literature summary extracted from

  • Chopra, I.
    Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents (2007), Curr. Opin. Investig. Drugs, 8, 600-607.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.6 medicine the enzyme is a promising target for the discovery of new antimicrobial agents Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 ABI-1131
-
 Escherichia coli
2.7.7.6 CBR-703
-
 Escherichia coli
2.7.7.6 corallopyronin A
-
 Escherichia coli
2.7.7.6 GE-23077-A
-
 Escherichia coli
2.7.7.6 GE-23077-B
-
 Escherichia coli
2.7.7.6 lipiarmycin
-
 Escherichia coli
2.7.7.6 additional information despite relatively high overall sequence and structural homology between bacterial and mammalian core RNAP enzymes, there are sufficient differences between the enzyme classes for exploitation in the discovery of selective bacterial inhibitors Escherichia coli
2.7.7.6 myxopyronin A
-
 Escherichia coli
2.7.7.6 rifabutin
-
 Escherichia coli
2.7.7.6 rifalazil
-
 Escherichia coli
2.7.7.6 ripostatin A
-
 Escherichia coli
2.7.7.6 SB-2
-
 Escherichia coli
2.7.7.6 sorangicin A
-
 Escherichia coli
2.7.7.6 Streptolydigin
-
 Escherichia coli
2.7.7.6 ureidothiophene
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn Escherichia coli enzyme is responsible for transcription in bacteria diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn
-
 Escherichia coli diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn enzyme is responsible for transcription in bacteria Escherichia coli diphosphate + RNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.6 More the core of the procaryotic RNAP comprises five subunits Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 RNAP
-
 Escherichia coli