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Literature summary extracted from

  • Chesney, J.
    6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis (2006), Curr. Opin. Clin. Nutr. Metab. Care, 9, 535-539.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.105 medicine the key role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in neoplastic transformation provides a rational for the development of agents that selectively inhibit the PFKFB3 enzyme as antineoplastic agents Homo sapiens
3.1.3.46 medicine PFKFB3 is constitutively expressed in human leukemias and solid tumor cells, inhibitors could act as antineoplastic agents Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.46 KDO-phosphatase knockout, enzyme is encoded by 4 genes, PFKFB1-4, PFKFB3 is activated by mitogenic, inflammatory and hypoxic stimuli Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 additional information Homo sapiens PFKFB3 is activated by mitogenic inflammatory and hypoxic stimuli. PFKFB4 controls glycolytic flux to lactate and the nonoxidatibe pentose shunt, and is selectively required for the tumorigenic growth of ras-transformed cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Homo sapiens
-
-
-
3.1.3.46 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 leukemia cell PFKFB3 is constitutively expressed Homo sapiens
-
3.1.3.46 cell culture
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 additional information PFKFB3 is activated by mitogenic inflammatory and hypoxic stimuli. PFKFB4 controls glycolytic flux to lactate and the nonoxidatibe pentose shunt, and is selectively required for the tumorigenic growth of ras-transformed cells Homo sapiens ?
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.105 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Homo sapiens
2.7.1.105 PFKFB3
-
 Homo sapiens
3.1.3.46 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Homo sapiens
3.1.3.46 PFK-2/FBPase
-
 Homo sapiens
3.1.3.46 PFKFB1
-
 Homo sapiens
3.1.3.46 PFKFB2
-
 Homo sapiens
3.1.3.46 PFKFB3
-
 Homo sapiens
3.1.3.46 PFKFB4
-
 Homo sapiens