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Literature summary extracted from

  • Di Santo, R.; Maga, G.
    Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy (2006), Curr. Med. Chem., 13, 2353-2368.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.31 (1R,2S)-1-(6-aminopurin-9-yl)-2-(Hydroxymethyl)cyclopentane
-
 Homo sapiens
2.7.7.31 3'-azido-TTP
-
 Homo sapiens
2.7.7.31 Ap5A
-
 Homo sapiens
2.7.7.31 cordycepin selectively cytotoxic against TdT+ leukemic cells, particularly in combination with the adenosine deaminase inhibitor deoxycoformycin Homo sapiens
2.7.7.31 D-/L-carbocyclic dideoxynucleoside triphosphates
-
 Homo sapiens
2.7.7.31 ddATP
-
 Homo sapiens
2.7.7.31 ddCTP
-
 Homo sapiens
2.7.7.31 ddGTP
-
 Homo sapiens
2.7.7.31 ddTTP
-
 Homo sapiens
2.7.7.31 P1,P5-diadenosine 5'-pentaphosphate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.31 Co2+
-
 Mus musculus
2.7.7.31 Co2+
-
 Homo sapiens
2.7.7.31 Mg2+
-
 Mus musculus
2.7.7.31 Mg2+
-
 Homo sapiens
2.7.7.31 Mn2+
-
 Mus musculus
2.7.7.31 Mn2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.31 Homo sapiens
-
-
-
2.7.7.31 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.31 bone marrow
-
 Homo sapiens
-
2.7.7.31 thymus
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.31 terminal deoxynucleotidyl transferase
-
 Homo sapiens
2.7.7.31 terminal deoxynucleotidyl transferase (TDT)
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.31 0.00025
-
 Ap5A
-
 Homo sapiens
2.7.7.31 0.0005
-
 (1R,2S)-1-(6-aminopurin-9-yl)-2-(Hydroxymethyl)cyclopentane
-
 Homo sapiens
2.7.7.31 0.0009 0.006 cordycepin
-
 Homo sapiens
2.7.7.31 0.0013
-
 ddATP
-
 Homo sapiens
2.7.7.31 0.0013
-
 ddGTP
-
 Homo sapiens
2.7.7.31 0.0028
-
 ddCTP
-
 Homo sapiens
2.7.7.31 0.005 0.01 D-/L-carbocyclic dideoxynucleoside triphosphates
-
 Homo sapiens
2.7.7.31 0.01
-
 3'-azido-TTP
-
 Homo sapiens
2.7.7.31 0.0175
-
 ddTTP
-
 Homo sapiens