EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.1.88 | medicine | target for the development of new antibacterial drugs | Haemophilus influenzae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.88 | 2-oxo-pyrrolidine with chelators | - |
Haemophilus influenzae | |
3.5.1.88 | 2-thioxo-4-thiazolidinone N-hexanoic acid | IC50 against Escherichia coli peptide deformylase: 0.00166 mM | Haemophilus influenzae | |
3.5.1.88 | actinonin | IC50 against Escherichia coli peptide deformylase: 0.0000003 mM | Haemophilus influenzae | |
3.5.1.88 | aldehyde peptide | IC50 against Escherichia coli peptide deformylase: 0.01 mM | Haemophilus influenzae | |
3.5.1.88 | alkyl-succinate-proline hydroxamate | IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM | Haemophilus influenzae | |
3.5.1.88 | benzimidazole N-formyl hydroxylamine | - |
Haemophilus influenzae | |
3.5.1.88 | benzothiazinone derivatives | IC50: 0.000005 mM | Haemophilus influenzae | |
3.5.1.88 | benzothiazolylidene hydroxamic acid derivatives | IC50 against Escherichia coli peptide deformylase: 0.00104 mM | Haemophilus influenzae | |
3.5.1.88 | beta-sulfonylhydroxamic acid | IC50 against Escherichia coli peptide deformylase: 0.000016 mM | Haemophilus influenzae | |
3.5.1.88 | carbamate N-formyl hydroxylamine | - |
Haemophilus influenzae | |
3.5.1.88 | heteroarylaryl(P2'/P3')N-formyl hydroxylamine | - |
Haemophilus influenzae | |
3.5.1.88 | hydantoin | IC50 against Escherichia coli peptide deformylase: 0.0002 mM | Haemophilus influenzae | |
3.5.1.88 | hydrazide N-formyl hydroxylamine | - |
Haemophilus influenzae | |
3.5.1.88 | isoxazole-3-hydroxamic acid derivatives | IC50 against Escherichia coli peptide deformylase: 0.0034 mM | Haemophilus influenzae | |
3.5.1.88 | N-alkyl urea hydroxamate | IC50 against Escherichia coli peptide deformylase: 0.000003 mM | Haemophilus influenzae | |
3.5.1.88 | N-hydroxy urea | IC50 against Escherichia coli peptide deformylase: 0.0022 mM | Haemophilus influenzae | |
3.5.1.88 | N-hydroxy-2-(substituted phenyl) acetamide | - |
Haemophilus influenzae | |
3.5.1.88 | N-hydroxy-N-(3-hydrazino-3-oxopropyl)formamide | - |
Haemophilus influenzae | |
3.5.1.88 | N-substituted methionine hydrazide | IC50 against Escherichia coli peptide deformylase: 0.2 mM | Haemophilus influenzae | |
3.5.1.88 | N-sulfonyl-L-Val-L-Leu-hydroxamate | - |
Haemophilus influenzae | |
3.5.1.88 | pseudopeptide metabolites | IC50 against Escherichia coli peptide deformylase: 0.000030 mM | Haemophilus influenzae | |
3.5.1.88 | pyrrolidine bicyclic(P2'/P3')compounds | - |
Haemophilus influenzae | |
3.5.1.88 | quinazoline hydroxamic acid | IC50 against Escherichia coli peptide deformylase: 0.00012 mM | Haemophilus influenzae | |
3.5.1.88 | thio peptide | IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif | Haemophilus influenzae | |
3.5.1.88 | thiol peptide | IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified | Haemophilus influenzae | |
3.5.1.88 | thyropropic acid derivatives | IC50 against Escherichia coli peptide deformylase: 0.001 mM | Haemophilus influenzae | |
3.5.1.88 | urea analogs(P2'/P3')of N-formyl hydroxylamine | - |
Haemophilus influenzae |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.88 | Fe2+ | - |
Haemophilus influenzae | |
3.5.1.88 | Ni2+ | - |
Haemophilus influenzae | |
3.5.1.88 | Zn2+ | - |
Haemophilus influenzae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | formyl-L-methionyl peptide + H2O | Haemophilus influenzae | - |
formate + methionyl peptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.88 | Haemophilus influenzae | - |
- |
- |
EC Number | Oxidation Stability | Organism |
---|---|---|
3.5.1.88 | ferrous ion in peptide deformylase is very unstable and is quickly and irreversibly oxidized to the ferric ion under laboratory conditions, resulting in an inactive enzyme. | Haemophilus influenzae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | formyl-L-methionyl peptide + H2O | - |
Haemophilus influenzae | formate + methionyl peptide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.88 | - |
Haemophilus influenzae | |
3.5.1.88 | peptide deformylase | - |
Haemophilus influenzae |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.5.1.88 | 0.0000003 | - |
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM | Haemophilus influenzae | actinonin | |
3.5.1.88 | 0.000003 | - |
IC50 against Escherichia coli peptide deformylase: 0.000003 mM | Haemophilus influenzae | N-alkyl urea hydroxamate | |
3.5.1.88 | 0.000004 | 0.00001 | IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM | Haemophilus influenzae | alkyl-succinate-proline hydroxamate | |
3.5.1.88 | 0.000005 | - |
IC50: 0.000005 mM | Haemophilus influenzae | benzothiazinone derivatives | |
3.5.1.88 | 0.000016 | - |
IC50 against Escherichia coli peptide deformylase: 0.000016 mM | Haemophilus influenzae | beta-sulfonylhydroxamic acid | |
3.5.1.88 | 0.000019 | - |
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif | Haemophilus influenzae | thio peptide | |
3.5.1.88 | 0.00003 | - |
IC50 against Escherichia coli peptide deformylase: 0.000030 mM | Haemophilus influenzae | pseudopeptide metabolites | |
3.5.1.88 | 0.00012 | - |
IC50 against Escherichia coli peptide deformylase: 0.00012 mM | Haemophilus influenzae | quinazoline hydroxamic acid | |
3.5.1.88 | 0.0002 | - |
IC50 against Escherichia coli peptide deformylase: 0.0002 mM | Haemophilus influenzae | hydantoin | |
3.5.1.88 | 0.001 | - |
IC50 against Escherichia coli peptide deformylase: 0.001 mM | Haemophilus influenzae | thyropropic acid derivatives | |
3.5.1.88 | 0.00104 | - |
IC50 against Escherichia coli peptide deformylase: 0.00104 mM | Haemophilus influenzae | benzothiazolylidene hydroxamic acid derivatives | |
3.5.1.88 | 0.00166 | - |
IC50 against Escherichia coli peptide deformylase: 0.00166 mM | Haemophilus influenzae | 2-thioxo-4-thiazolidinone N-hexanoic acid | |
3.5.1.88 | 0.0022 | - |
IC50 against Escherichia coli peptide deformylase: 0.0022 mM | Haemophilus influenzae | N-hydroxy urea | |
3.5.1.88 | 0.0025 | - |
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified | Haemophilus influenzae | thiol peptide | |
3.5.1.88 | 0.0034 | - |
IC50 against Escherichia coli peptide deformylase: 0.0034 mM | Haemophilus influenzae | isoxazole-3-hydroxamic acid derivatives | |
3.5.1.88 | 0.01 | - |
IC50 against Escherichia coli peptide deformylase: 0.01 mM | Haemophilus influenzae | aldehyde peptide | |
3.5.1.88 | 0.2 | - |
IC50 against Escherichia coli peptide deformylase: 0.2 mM | Haemophilus influenzae | N-substituted methionine hydrazide |