Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jain, R.; Chen, D.; White, R.J.; Patel, D.V.; Yuan, Z.
    Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents (2005), Curr. Med. Chem., 12, 1607-1621.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.88 medicine target for the development of new antibacterial drugs Haemophilus influenzae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.88 2-oxo-pyrrolidine with chelators
-
Haemophilus influenzae
3.5.1.88 2-thioxo-4-thiazolidinone N-hexanoic acid IC50 against Escherichia coli peptide deformylase: 0.00166 mM Haemophilus influenzae
3.5.1.88 actinonin IC50 against Escherichia coli peptide deformylase: 0.0000003 mM Haemophilus influenzae
3.5.1.88 aldehyde peptide IC50 against Escherichia coli peptide deformylase: 0.01 mM Haemophilus influenzae
3.5.1.88 alkyl-succinate-proline hydroxamate IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM Haemophilus influenzae
3.5.1.88 benzimidazole N-formyl hydroxylamine
-
Haemophilus influenzae
3.5.1.88 benzothiazinone derivatives IC50: 0.000005 mM Haemophilus influenzae
3.5.1.88 benzothiazolylidene hydroxamic acid derivatives IC50 against Escherichia coli peptide deformylase: 0.00104 mM Haemophilus influenzae
3.5.1.88 beta-sulfonylhydroxamic acid IC50 against Escherichia coli peptide deformylase: 0.000016 mM Haemophilus influenzae
3.5.1.88 carbamate N-formyl hydroxylamine
-
Haemophilus influenzae
3.5.1.88 heteroarylaryl(P2'/P3')N-formyl hydroxylamine
-
Haemophilus influenzae
3.5.1.88 hydantoin IC50 against Escherichia coli peptide deformylase: 0.0002 mM Haemophilus influenzae
3.5.1.88 hydrazide N-formyl hydroxylamine
-
Haemophilus influenzae
3.5.1.88 isoxazole-3-hydroxamic acid derivatives IC50 against Escherichia coli peptide deformylase: 0.0034 mM Haemophilus influenzae
3.5.1.88 N-alkyl urea hydroxamate IC50 against Escherichia coli peptide deformylase: 0.000003 mM Haemophilus influenzae
3.5.1.88 N-hydroxy urea IC50 against Escherichia coli peptide deformylase: 0.0022 mM Haemophilus influenzae
3.5.1.88 N-hydroxy-2-(substituted phenyl) acetamide
-
Haemophilus influenzae
3.5.1.88 N-hydroxy-N-(3-hydrazino-3-oxopropyl)formamide
-
Haemophilus influenzae
3.5.1.88 N-substituted methionine hydrazide IC50 against Escherichia coli peptide deformylase: 0.2 mM Haemophilus influenzae
3.5.1.88 N-sulfonyl-L-Val-L-Leu-hydroxamate
-
Haemophilus influenzae
3.5.1.88 pseudopeptide metabolites IC50 against Escherichia coli peptide deformylase: 0.000030 mM Haemophilus influenzae
3.5.1.88 pyrrolidine bicyclic(P2'/P3')compounds
-
Haemophilus influenzae
3.5.1.88 quinazoline hydroxamic acid IC50 against Escherichia coli peptide deformylase: 0.00012 mM Haemophilus influenzae
3.5.1.88 thio peptide IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif Haemophilus influenzae
3.5.1.88 thiol peptide IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified Haemophilus influenzae
3.5.1.88 thyropropic acid derivatives IC50 against Escherichia coli peptide deformylase: 0.001 mM Haemophilus influenzae
3.5.1.88 urea analogs(P2'/P3')of N-formyl hydroxylamine
-
Haemophilus influenzae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.88 Fe2+
-
Haemophilus influenzae
3.5.1.88 Ni2+
-
Haemophilus influenzae
3.5.1.88 Zn2+
-
Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.88 formyl-L-methionyl peptide + H2O Haemophilus influenzae
-
formate + methionyl peptide
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.88 Haemophilus influenzae
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
3.5.1.88 ferrous ion in peptide deformylase is very unstable and is quickly and irreversibly oxidized to the ferric ion under laboratory conditions, resulting in an inactive enzyme. Haemophilus influenzae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.88 formyl-L-methionyl peptide + H2O
-
Haemophilus influenzae formate + methionyl peptide
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.88 PDF
-
Haemophilus influenzae
3.5.1.88 peptide deformylase
-
Haemophilus influenzae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.88 0.0000003
-
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM Haemophilus influenzae actinonin
3.5.1.88 0.000003
-
IC50 against Escherichia coli peptide deformylase: 0.000003 mM Haemophilus influenzae N-alkyl urea hydroxamate
3.5.1.88 0.000004 0.00001 IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM Haemophilus influenzae alkyl-succinate-proline hydroxamate
3.5.1.88 0.000005
-
IC50: 0.000005 mM Haemophilus influenzae benzothiazinone derivatives
3.5.1.88 0.000016
-
IC50 against Escherichia coli peptide deformylase: 0.000016 mM Haemophilus influenzae beta-sulfonylhydroxamic acid
3.5.1.88 0.000019
-
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif Haemophilus influenzae thio peptide
3.5.1.88 0.00003
-
IC50 against Escherichia coli peptide deformylase: 0.000030 mM Haemophilus influenzae pseudopeptide metabolites
3.5.1.88 0.00012
-
IC50 against Escherichia coli peptide deformylase: 0.00012 mM Haemophilus influenzae quinazoline hydroxamic acid
3.5.1.88 0.0002
-
IC50 against Escherichia coli peptide deformylase: 0.0002 mM Haemophilus influenzae hydantoin
3.5.1.88 0.001
-
IC50 against Escherichia coli peptide deformylase: 0.001 mM Haemophilus influenzae thyropropic acid derivatives
3.5.1.88 0.00104
-
IC50 against Escherichia coli peptide deformylase: 0.00104 mM Haemophilus influenzae benzothiazolylidene hydroxamic acid derivatives
3.5.1.88 0.00166
-
IC50 against Escherichia coli peptide deformylase: 0.00166 mM Haemophilus influenzae 2-thioxo-4-thiazolidinone N-hexanoic acid
3.5.1.88 0.0022
-
IC50 against Escherichia coli peptide deformylase: 0.0022 mM Haemophilus influenzae N-hydroxy urea
3.5.1.88 0.0025
-
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified Haemophilus influenzae thiol peptide
3.5.1.88 0.0034
-
IC50 against Escherichia coli peptide deformylase: 0.0034 mM Haemophilus influenzae isoxazole-3-hydroxamic acid derivatives
3.5.1.88 0.01
-
IC50 against Escherichia coli peptide deformylase: 0.01 mM Haemophilus influenzae aldehyde peptide
3.5.1.88 0.2
-
IC50 against Escherichia coli peptide deformylase: 0.2 mM Haemophilus influenzae N-substituted methionine hydrazide