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Literature summary extracted from

  • Rachdan, D.; Lou, M.F.; Harding, J.J.
    Glutathione reductase from human cataract lenses can be revived by reducing agents and by a molecular chaperone, alpha-crystallin (2005), Curr. Eye Res., 30, 919-925.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.7 alpha-crystallin 2 mg/ml causes 37% increase in activity, 1 mg/ml causes 20% enhancement Homo sapiens
1.8.1.7 captopril 5-10 mM, the best enhancement (30%) is achieved using 10 mM Homo sapiens
1.8.1.7 DL-dithiothreitol 0.25-4 mM, the best enhancement of activity (96.6%) is obtained by a concentration of 1 mM Homo sapiens
1.8.1.7 GSH 0.25 mM, 37% enhancement of activity Homo sapiens
1.8.1.7 thioltransferase 1 unit, 43% enhancement of activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 captopril 20 mM, 46.6% decrease of activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 lens
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 EC 1.6.4.2 formerly Homo sapiens
1.8.1.7 glutathione reductase
-
 Homo sapiens
1.8.1.7 GR
-
 Homo sapiens