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Literature summary extracted from

  • Solien, J.; Haynes, V.; Giulivi, C.
    Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: Impact on the regulation of mitochondrial oxygen consumption (2005), Comp. Biochem. Physiol. A, 142A, 111-117.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.2 ruthenium red abolishes the Ca-stimulation of OGDH Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.2 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.4.2 Ca2+ activation of OGDH, followed by an increase in oxygen consumption under normoxic conditions, during hypoxia accumulation of Ca2+ in mitochondria Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.2 2-ketoglutarate dehydrogenase
-
 Rattus norvegicus
1.2.4.2 2-oxoglutarate dehydrogenase
-
 Rattus norvegicus
1.2.4.2 OGDH
-
 Rattus norvegicus
1.2.4.2 oxoglutarate dehydrogenase
-
 Rattus norvegicus