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Literature summary extracted from

  • Comai, S.; Costa, C.V.; Ragazzi, E.; Bertazzo, A.; Allegri, G.
    The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats (2005), Clin. Chim. Acta, 360, 67-80.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.7.1.3 medicine progressive decline in the enzyme activity involved in tryptophan metabolism along the kynurenine pathway in rat tissue with age Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.9 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.9 kynurenine + NADPH + O2 Rattus norvegicus
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 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 additional information Rattus norvegicus age affects the enzyme activities of tryptophan metabolism along the kynurenine pathway, one of the various tryptophan metabolic routes, kynurenine 3-monooxygenase activity progressively decreases with age in liver and kidney of newborn to mature rats, quantitative overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.6 Rattus norvegicus
-
-
-
1.13.11.17 Rattus norvegicus
-
-
-
1.13.11.52 Rattus norvegicus
-
-
-
1.14.13.9 Rattus norvegicus
-
 Sprague–Dawley rats of ages 1 week, 2–3, 12 and 18 months
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3.7.1.3 Rattus norvegicus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.6 kidney activity is low in newborn, significantly incrEases and remains elevated through the following ages Rattus norvegicus
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1.13.11.6 liver specific activity progressively and significantly increases from newborns to 12 months of age Rattus norvegicus
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1.13.11.17 small intestine activity is present in relevant amounts even in newborn rats. The specific activity increases significantly in young rats by about 44% in comparison to newborns Rattus norvegicus
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1.13.11.52 liver activity is low in newborn rats, increases up to the age of 2-3 months and decreases from 3 months of age to 18 months Rattus norvegicus
-
1.14.13.9 kidney enzyme activity decreases significantly with age Rattus norvegicus
-
1.14.13.9 liver enzyme activity decreases significantly with age Rattus norvegicus
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1.14.13.9 small intestine
-
 Rattus norvegicus
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3.7.1.3 kidney enzyme activity is very low in newborn rats, but increases in rats of 2-3 months to 18 months of age, without an evident age-related pattern Rattus norvegicus
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3.7.1.3 liver enzyme activity declines with age, similar in newborns and 2-3 month-old rats, activity decreases markedly by ca. 60% and 70% at 12 and 18 months, respectively Rattus norvegicus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.9 0.000012
-
 liver of 2-3 months-old rats Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-Trp + O2
-
 Rattus norvegicus L-formylkynurenine
-
 ?
1.14.13.9 kynurenine + NADPH + O2
-
 Rattus norvegicus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 additional information age affects the enzyme activities of tryptophan metabolism along the kynurenine pathway, one of the various tryptophan metabolic routes, kynurenine 3-monooxygenase activity progressively decreases with age in liver and kidney of newborn to mature rats, quantitative overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase
-
 Rattus norvegicus
1.13.11.17 indole 2,3-dioxygenase
-
 Rattus norvegicus
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Rattus norvegicus
3.7.1.3 L-kynurenine hydrolase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.9 NADPH
-
 Rattus norvegicus