Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tomkinson, A.E.; Vijayakumar, S.; Pascal, J.M.; Ellenberger, T.
    DNA ligases: Structure, reaction mechanism, and function (2006), Chem. Rev., 106, 687-699.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1
-
Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.5.1.1 crystal structure of human DNA ligase I bound to nicked, 5'-adenylated DNA. The crystal structure of human DNA ligase I complexed to DNA demonstrates that the enzyme encircles its DNA substrate Homo sapiens
6.5.1.2
-
Thermus filiformis
6.5.1.2
-
Enterococcus faecalis

General Stability

EC Number General Stability Organism
6.5.1.1 DNA ligase IV depends on the partner protein XRCC4 for stability and activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.5.1.1 nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens detection and characterization of a direct physical interaction between DNA ligase I, proliferating cell nuclear antigen, a DNA sliding clamp, and, more recently, an interaction between DNA ligase I and replication factor C, the sliding clamp loader AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens mitochondrial DNA ligase IIIalpha is critical for the mitochondrial function, role of DNA ligase IIIbeta in gametogenesis AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Escherichia phage T7 P00969
-
-
6.5.1.1 Homo sapiens P18858
-
-
6.5.1.2 Enterococcus faecalis Q837V6
-
-
6.5.1.2 Thermus filiformis Q9ZHI0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m detection and characterization of a direct physical interaction between DNA ligase I, proliferating cell nuclear antigen, a DNA sliding clamp, and, more recently, an interaction between DNA ligase I and replication factor C, the sliding clamp loader Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m mitochondrial DNA ligase IIIalpha is critical for the mitochondrial function, role of DNA ligase IIIbeta in gametogenesis Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
6.5.1.1 additional information the ATP-dependent DNA ligase from bacteriophage T7 is a two-domain ligase: the adenylation or nucleotide-binding domain binds ATP and is connected to an OB-fold domain by a flexible linker. The ATP-binding pocket within the amino-terminal domain of bacteriophage T7 is formed by two antiparallel beta-sheets flanked by R-helices Escherichia phage T7 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 ATP-dependent DNA ligase
-
Escherichia phage T7
6.5.1.1 DNA ligase I
-
Homo sapiens
6.5.1.1 DNA ligase III
-
Homo sapiens
6.5.1.1 DNA ligase IV
-
Homo sapiens
6.5.1.2 NAD+-dependent DNA ligase
-
Thermus filiformis
6.5.1.2 NAD+-dependent DNA ligase
-
Enterococcus faecalis