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Literature summary extracted from

  • Helleday, T.; Bryant, H.E.; Schultz, N.
    Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy (2005), Cell Cycle, 4, 1176-1178.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.30 additional information DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview Mus musculus

Application

EC Number Application Comment Organism
2.4.2.30 pharmacology the enzyme inhibition is a possible tool in cancer therapy both in prophylactic and therapeutic treatment, e.g. by targeting BRCA2 tumors with PARP inhibitors, overview Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.30 additional information PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, cells isolated from these mice show an increased level of homologous recombination Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 additional information Mus musculus role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Mus musculus
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ mechanism and physiological function, overview Mus musculus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 additional information role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins Mus musculus ?
-
 ?
2.4.2.30 additional information PARP-1 protein has an N-terminal DNA binding domain containing two large zinc fingers that bind to both DNA single-strand breaks and DNA double-strand breaks, DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview Mus musculus ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Mus musculus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.30 More PARP-1 protein has an N-terminal DNA binding domain containing two large zinc fingers that bind to both DNA single-strand breaks and DNA double-strand breaks Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 PARP-1
-
 Mus musculus
2.4.2.30 poly(ADP-ribose) polymerase
-
 Mus musculus