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Literature summary extracted from

  • Wallace, T.A.; Sayeski, P.P.
    Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression? (2006), Cell Biochem. Biophys., 44, 213-222.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 cytokine receptors
-
Drosophila melanogaster
2.7.10.2 cytokine receptors
-
Mus musculus
2.7.10.2 cytokine receptors
-
Homo sapiens
2.7.10.2 additional information different activation mechanisms for Jak2 Drosophila melanogaster
2.7.10.2 additional information different activation mechanisms for Jak2 Mus musculus
2.7.10.2 additional information different activation mechanisms for Jak2 Homo sapiens
2.7.10.2 tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors Drosophila melanogaster
2.7.10.2 tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors Mus musculus
2.7.10.2 tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 E695K mutation in the JH2 domain of the Jak homologue hopscotch, which renders the kinase hyperactive and causes hematopoietic hyperplasia Drosophila melanogaster
2.7.10.2 additional information construction of a transcription factor TEL-Jak2 fusion chimeric protein, leading to increase in nuclear factor IkappaB and growthfactor-independent cell proliferation, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 cytosol
-
Drosophila melanogaster 5829
-
2.7.10.2 cytosol
-
Mus musculus 5829
-
2.7.10.2 cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.2 130000
-
approximately Drosophila melanogaster
2.7.10.2 130000
-
approximately Mus musculus
2.7.10.2 130000
-
approximately Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 additional information Drosophila melanogaster Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview ?
-
?
2.7.10.2 additional information Mus musculus Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview ?
-
?
2.7.10.2 additional information Homo sapiens Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview ?
-
?
2.7.10.2 STAT transcription activator protein + ATP Drosophila melanogaster activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP Mus musculus activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP Homo sapiens activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview phosphorylated STAT transcription activator protein + ADP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Drosophila melanogaster
-
-
-
2.7.10.2 Homo sapiens
-
-
-
2.7.10.2 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein phosphorylation of the activation loop is required for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation Drosophila melanogaster
2.7.10.2 phosphoprotein phosphorylation of the activation loop is required for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation Homo sapiens
2.7.10.2 phosphoprotein phosphorylation of the activation loop, especially at Tyr1007, is essential for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 lymphocyte
-
Mus musculus
-
2.7.10.2 additional information the enzyme shows a wide tissue distribution Drosophila melanogaster
-
2.7.10.2 additional information the enzyme shows a wide tissue distribution Mus musculus
-
2.7.10.2 additional information the enzyme shows a wide tissue distribution Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Drosophila melanogaster ?
-
?
2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Mus musculus ?
-
?
2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Homo sapiens ?
-
?
2.7.10.2 additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Drosophila melanogaster ?
-
?
2.7.10.2 additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Mus musculus ?
-
?
2.7.10.2 additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Homo sapiens ?
-
?
2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Drosophila melanogaster phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Mus musculus phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Homo sapiens phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Drosophila melanogaster phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Mus musculus phosphorylated STAT transcription activator protein + ADP
-
?
2.7.10.2 STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Homo sapiens phosphorylated STAT transcription activator protein + ADP
-
?

Subunits

EC Number Subunits Comment Organism
2.7.10.2 More domain structure including catalytic and ligand binding domains, and an activation loop spanning from Asp994 to Glu1024, the domains are termed JH1 to JH7, overview Mus musculus
2.7.10.2 More domain structure including catalytic and ligand binding domains, and an activation loop, the domains are termed JH1 to JH7, overview Drosophila melanogaster
2.7.10.2 More domain structure including catalytic and ligand binding domains, and an activation loop, the domains are termed JH1 to JH7, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 JAK2
-
Drosophila melanogaster
2.7.10.2 JAK2
-
Mus musculus
2.7.10.2 JAK2
-
Homo sapiens
2.7.10.2 More the enzyme belongs to the Janus family of tyrosine kinases Drosophila melanogaster
2.7.10.2 More the enzyme belongs to the Janus family of tyrosine kinases Mus musculus
2.7.10.2 More the enzyme belongs to the Janus family of tyrosine kinases Homo sapiens
2.7.10.2 nonreceptor tyrosine kinase
-
Drosophila melanogaster
2.7.10.2 nonreceptor tyrosine kinase
-
Mus musculus
2.7.10.2 nonreceptor tyrosine kinase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
Drosophila melanogaster
2.7.10.2 ATP
-
Mus musculus
2.7.10.2 ATP
-
Homo sapiens