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Literature summary extracted from

  • Mattiazzi, A.; Vittone, L.; Mundina-Weilenmann, C.
    Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis (2007), Cardiovasc. Res., 73, 648-656.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-93
-
 Rattus norvegicus
2.7.11.17 additional information Ca2+ binds to the autoregulatory region of the enzyme disrupting autoinhibitory interactions and allowing access to the catalytic site for substrate and ATP Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 sarcoplasmic reticulum
-
 Rattus norvegicus 16529
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, binds to the autoregulatory region of the enzyme disrupting autoinhibitory interactions Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + NHE-1 Rattus norvegicus phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger ADP + phosphorylated NHE-1
-
 ?
2.7.11.17 ATP + PLN Rattus norvegicus phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition ADP + phosphorylated PLN
-
 ?
2.7.11.17 additional information Rattus norvegicus CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 cardiomyocyte
-
 Rattus norvegicus
-
2.7.11.17 heart
-
 Rattus norvegicus
-
2.7.11.17 muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + NHE-1 phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger Rattus norvegicus ADP + phosphorylated NHE-1
-
 ?
2.7.11.17 ATP + NHE-1 a Na+-H+-exchanging protein, phosphorylation by CaMKII at the intracellular cytoplasmic domain Rattus norvegicus ADP + phosphorylated NHE-1
-
 ?
2.7.11.17 ATP + PLN phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition Rattus norvegicus ADP + phosphorylated PLN
-
 ?
2.7.11.17 ATP + PLN a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17 Rattus norvegicus ADP + phosphorylated PLN
-
 ?
2.7.11.17 additional information CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 oligomer CaMKII is a multimeric holoenzyme composed of six to twelve subunits encoded by 4 separate genes Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus