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Literature summary extracted from

  • Maier, L.S.; Bers, D.M.
    Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart (2007), Cardiovasc. Res., 73, 631-640.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Mus musculus
2.7.11.17 Calmodulin dependent on Homo sapiens
2.7.11.17 Calmodulin dependent on Oryctolagus cuniculus
2.7.11.17 additional information after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole Mus musculus
2.7.11.17 additional information after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole Homo sapiens
2.7.11.17 additional information after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole Oryctolagus cuniculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 overexpression of isozyme CaMKIIdeltaC in transgenic mouse myocytes or in rabbit myocytes using adenoviral transfection, affects on Ca2+ influx, Ca2+ current, and inhibition of Ca2+ channel inhibition through phosphorylation, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 AC3-I peptide i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII Mus musculus
2.7.11.17 AIP peptide i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Mus musculus
2.7.11.17 KN62 inhibits CaMKII Homo sapiens
2.7.11.17 KN62 inhibits CaMKII Mus musculus
2.7.11.17 KN62 inhibits CaMKII Oryctolagus cuniculus
2.7.11.17 KN93 inhibits CaMKII Homo sapiens
2.7.11.17 KN93 inhibits CaMKII Mus musculus
2.7.11.17 KN93 inhibits CaMKII Oryctolagus cuniculus
2.7.11.17 additional information the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding Homo sapiens
2.7.11.17 additional information the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding Mus musculus
2.7.11.17 additional information the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding Oryctolagus cuniculus
2.7.11.17 peptide AC3-I i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII Homo sapiens
2.7.11.17 peptide AC3-I i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII Oryctolagus cuniculus
2.7.11.17 peptide AIP i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Homo sapiens
2.7.11.17 peptide AIP i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytosol
-
 Mus musculus 5829
-
2.7.11.17 cytosol
-
 Homo sapiens 5829
-
2.7.11.17 cytosol
-
 Oryctolagus cuniculus 5829
-
2.7.11.17 sarcoplasmic reticulum associated Mus musculus 16529
-
2.7.11.17 sarcoplasmic reticulum associated Homo sapiens 16529
-
2.7.11.17 sarcoplasmic reticulum associated Oryctolagus cuniculus 16529
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Mus musculus
2.7.11.17 Ca2+ dependent on Homo sapiens
2.7.11.17 Ca2+ dependent on Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + L-type Ca2+ channel Mus musculus inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel Homo sapiens inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel Oryctolagus cuniculus inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + PLB Mus musculus a regulatory protein in Ca2+ signaling ADP + phosphorylated PLB
-
 ?
2.7.11.17 ATP + protein PLB Homo sapiens a regulatory protein in Ca2+ signaling ADP + phosphorylated protein PLB
-
 ?
2.7.11.17 ATP + protein PLB Oryctolagus cuniculus a regulatory protein in Ca2+ signaling ADP + phosphorylated protein PLB
-
 ?
2.7.11.17 ATP + protein RyR Homo sapiens a regulatory protein in Ca2+ signaling ADP + phosphorylated protein RyR
-
 ?
2.7.11.17 ATP + protein RyR Oryctolagus cuniculus a regulatory protein in Ca2+ signaling ADP + phosphorylated protein RyR
-
 ?
2.7.11.17 ATP + RyR Mus musculus a regulatory protein in Ca2+ signaling ADP + phosphorylated RyR
-
 ?
2.7.11.17 additional information Mus musculus modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview ?
-
 ?
2.7.11.17 additional information Homo sapiens modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview ?
-
 ?
2.7.11.17 additional information Oryctolagus cuniculus modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
-
-
2.7.11.17 Mus musculus
-
-
-
2.7.11.17 Oryctolagus cuniculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaMKII is autophosphorylated Mus musculus
2.7.11.17 phosphoprotein CaMKII is autophosphorylated Homo sapiens
2.7.11.17 phosphoprotein CaMKII is autophosphorylated Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 heart
-
 Mus musculus
-
2.7.11.17 heart
-
 Homo sapiens
-
2.7.11.17 heart
-
 Oryctolagus cuniculus
-
2.7.11.17 myocyte
-
 Mus musculus
-
2.7.11.17 myocyte
-
 Homo sapiens
-
2.7.11.17 myocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + L-type Ca2+ channel inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias Mus musculus ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias Homo sapiens ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias Oryctolagus cuniculus ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel inactivation by CaMKII Mus musculus ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel inactivation by CaMKII Homo sapiens ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + L-type Ca2+ channel inactivation by CaMKII Oryctolagus cuniculus ADP + phosphorylated L-type Ca2+ channel
-
 ?
2.7.11.17 ATP + PLB a regulatory protein in Ca2+ signaling Mus musculus ADP + phosphorylated PLB
-
 ?
2.7.11.17 ATP + protein PLB a regulatory protein in Ca2+ signaling Homo sapiens ADP + phosphorylated protein PLB
-
 ?
2.7.11.17 ATP + protein PLB a regulatory protein in Ca2+ signaling Oryctolagus cuniculus ADP + phosphorylated protein PLB
-
 ?
2.7.11.17 ATP + protein RyR a regulatory protein in Ca2+ signaling Homo sapiens ADP + phosphorylated protein RyR
-
 ?
2.7.11.17 ATP + protein RyR a regulatory protein in Ca2+ signaling Oryctolagus cuniculus ADP + phosphorylated protein RyR
-
 ?
2.7.11.17 ATP + RyR a regulatory protein in Ca2+ signaling Mus musculus ADP + phosphorylated RyR
-
 ?
2.7.11.17 additional information modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview Mus musculus ?
-
 ?
2.7.11.17 additional information modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview Homo sapiens ?
-
 ?
2.7.11.17 additional information modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview Oryctolagus cuniculus ?
-
 ?
2.7.11.17 additional information CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview Mus musculus ?
-
 ?
2.7.11.17 additional information CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview Homo sapiens ?
-
 ?
2.7.11.17 additional information CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 monomer CaMKIV and CaMKI Mus musculus
2.7.11.17 monomer CaMKIV and CaMKI Homo sapiens
2.7.11.17 monomer CaMKIV and CaMKI Oryctolagus cuniculus
2.7.11.17 multimer CaMKII, homo-and heteromultimers Mus musculus
2.7.11.17 multimer CaMKII, homo-and heteromultimers Homo sapiens
2.7.11.17 multimer CaMKII, homo-and heteromultimers Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 CaMKI
-
 Mus musculus
2.7.11.17 CaMKI
-
 Homo sapiens
2.7.11.17 CaMKI
-
 Oryctolagus cuniculus
2.7.11.17 CaMKII
-
 Mus musculus
2.7.11.17 CaMKII
-
 Homo sapiens
2.7.11.17 CaMKII
-
 Oryctolagus cuniculus
2.7.11.17 CaMKIV
-
 Mus musculus
2.7.11.17 CaMKIV
-
 Homo sapiens
2.7.11.17 CaMKIV
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus
2.7.11.17 ATP
-
 Homo sapiens
2.7.11.17 ATP
-
 Oryctolagus cuniculus