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Literature summary extracted from

  • Cassidy, P.B.; Edes, K.; Nelson, C.C.; Parsawar, K.; Fitzpatrick, F.A.; Moos, P.J.
    Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles (2006), Carcinogenesis, 27, 2538-2549.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 15-deoxy-D-12,14-PGJ2 0.06 mM, IC50: 0.00036 mM Rattus norvegicus
1.8.1.9 3,4-estronequinone 0.032 mM, IC50: 0.02 mM Rattus norvegicus
1.8.1.9 4-hydroxynonenal 0.06 mM, IC50: 0.012 mM Rattus norvegicus
1.8.1.9 leukotriene A4 methyl ester 0.06 mM, IC50: 0.513 mM Rattus norvegicus
1.8.1.9 Prostaglandin A2 0.06 mM, IC50: 0.068 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.9 DE52 column chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin + NADP+
-
 Rattus norvegicus thioredoxin disulfide + NADPH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.1.9 homodimer
-
 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Rattus norvegicus
1.8.1.9 TrxR
-
 Rattus norvegicus
1.8.1.9 TrxR1
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.9 0.000024
-
 15-deoxy-D-12,14-PGJ2
-
 Rattus norvegicus
1.8.1.9 0.0008
-
 4-hydroxynonenal
-
 Rattus norvegicus
1.8.1.9 0.001
-
 3,4-estronequinone
-
 Rattus norvegicus
1.8.1.9 0.0045
-
 Prostaglandin A2
-
 Rattus norvegicus
1.8.1.9 0.033
-
 leukotriene A4 methyl ester
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.9 0.00036
-
 0.06 mM, IC50: 0.00036 mM Rattus norvegicus 15-deoxy-D-12,14-PGJ2
1.8.1.9 0.012
-
 0.06 mM, IC50: 0.012 mM Rattus norvegicus 4-hydroxynonenal
1.8.1.9 0.02
-
 0.032 mM, IC50: 0.02 mM Rattus norvegicus 3,4-estronequinone
1.8.1.9 0.068
-
 0.06 mM, IC50: 0.068 mM Rattus norvegicus Prostaglandin A2
1.8.1.9 0.513
-
 0.06 mM, IC50: 0.513 mM Rattus norvegicus leukotriene A4 methyl ester