Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sakurai, Y.; Sakamoto, K.; Sugimoto, Y.; Yoshida, I.; Masui, T.; Tonomura, S.; Inaba, K.; Shoji, M.; Nakamura, Y.; Uyama, I.; Komori, Y.; Ochiai, M.; Matsuura, S.; Tanaka, H.; Oka, T.; Fukushima, M.
    Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma (2006), Cancer Sci., 97, 492-498.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.10 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.10 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview 5-fluorouridine 5'-phosphate + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.10 cholangioma cell
-
 Homo sapiens
-
2.4.2.10 colonic cancer cell
-
 Homo sapiens
-
2.4.2.10 gastric carcinoma cell
-
 Homo sapiens
-
2.4.2.10 lung cancer cell
-
 Homo sapiens
-
2.4.2.10 prostate cancer cell
-
 Homo sapiens
-
2.4.2.10 uterine cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.10 additional information
-
 ELISA assay method development and evaluation for enzyme detection and quantification in cancer tissue, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.10 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
2.4.2.10 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.10 OPRT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.10 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.10 8
-
 assay at Homo sapiens