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Literature summary extracted from

  • Smal, C.; Van Den Neste, E.; Maerevoet, M.; Poire, X.; Theate, I.; Bontemps, F.
    Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukemia lymphocytes (2007), Cancer Lett., 253, 68-73.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 2-chloro-2'-deoxyadenosine increases activity by increasing phosphorylation of Ser74 Homo sapiens
2.7.1.74 aphidicolin increases activity by increasing phosphorylation of Ser74 Homo sapiens
2.7.1.74 etoposide increases activity by increasing phosphorylation of Ser74 Homo sapiens
2.7.1.74 genistein increases activity by increasing phosphorylation of Ser74 Homo sapiens
2.7.1.74 additional information UV-C irradiation increases activity by increasing phosphorylation of Ser74 Homo sapiens

Application

EC Number Application Comment Organism
2.7.1.74 analysis deoxycytidine kinase from B-cell chronic lymphocytic leukaemia lymphocytes can be detected by use of anti-phospho-ser74 antibodies Homo sapiens
2.7.1.74 medicine interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.74 expressed in HEK 293T cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+ in complex with ATP Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 NTP + 2-chloro-2'-deoxyadenosine Homo sapiens phosphorylation of chemotherapeutically important nucleoside analogues NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 NTP + 9-beta-D-arabinosyl-2-fluoroadenine Homo sapiens phosphorylation of chemotherapeutically important nucleoside analogues NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-
2.7.1.74 Homo sapiens
-
 patients with B-cell chronic lymphocytic leukaemia
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.74 phosphoprotein regulation of activity by phosphorylation of Ser-74 Homo sapiens
2.7.1.74 phosphoprotein interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 B-CLL cell
-
 Homo sapiens
-
2.7.1.74 blood
-
 Homo sapiens
-
2.7.1.74 lymphocyte B-cell chronic lymphocytic leukaemia lymphocyte Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxy-CMP
-
 ?
2.7.1.74 NTP + 2-chloro-2'-deoxyadenosine phosphorylation of chemotherapeutically important nucleoside analogues Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 NTP + 9-beta-D-arabinosyl-2-fluoroadenine phosphorylation of chemotherapeutically important nucleoside analogues Homo sapiens NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens