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Literature summary extracted from

  • Bierau, J.; van Gennip, A.H.; Leen, R.; Meinsma, R.; Caron, H.N.; van Kuilenburg, A.B.
    Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma (2006), Cancer Chemother. Pharmacol., 57, 105-113.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 additional information enzyme protein level increases when cells are incubated with cyclopentenyl cytosine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 NTP + 2',2'-difluorodeoxycytidine Homo sapiens i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
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?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 SK-N-BE(2) cell
-
Homo sapiens
-
2.7.1.74 SK-N-SH cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 NTP + 2',2'-difluorodeoxycytidine i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors Homo sapiens NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
Homo sapiens