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Literature summary extracted from

  • Traer, C.J.; Foster, F.M.; Abraham, S.M.; Fry, M.J.
    Are class II posphoinositide 3-kinases potential targets for anticancer therapies? (2006), Bull. Cancer, 93, E53-E58.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.154 membrane predominantly localised to intracellular membranes Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.154 additional information Homo sapiens PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking. ?
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 ?
2.7.1.154 additional information Homo sapiens PI3KC2beta functions in cell migration, and PTK receptor signalling ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.154 Homo sapiens O00443
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2.7.1.154 Homo sapiens O00750
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2.7.1.154 Homo sapiens O75747
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.154 breast PI3KC2gamma Homo sapiens
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2.7.1.154 liver PI3KC2gamma Homo sapiens
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2.7.1.154 additional information widely expressed, but not ubiquitous Homo sapiens
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2.7.1.154 prostate PI3KC2gamma Homo sapiens
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2.7.1.154 thymus high activity of PI3KC2beta Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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 ?
2.7.1.154 ATP + phosphatidylinositol
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 Homo sapiens ADP + phosphatidylinositol 3-phosphate
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 ?
2.7.1.154 additional information PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking. Homo sapiens ?
-
 ?
2.7.1.154 additional information PI3KC2beta functions in cell migration, and PTK receptor signalling Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.154 PI3KC2alpha
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 Homo sapiens
2.7.1.154 PI3KC2beta
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 Homo sapiens
2.7.1.154 PI3KC2gamma
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 Homo sapiens