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Literature summary extracted from

  • Takeda, H.; Kitaoka, Y.; Hayashi, Y.; Kumai, T.; Munemasa, Y.; Fujino, H.; Kobayashi, S.; Ueno, S.
    Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity (2007), Brain Res., 1184, 306-3015.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin
-
 Rattus norvegicus
2.7.11.17 additional information N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 additional information CaMKII downregulation by CaMKII small interfering RNA in retinal cells Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+
-
 Rattus norvegicus
2.7.11.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + protein CREB Rattus norvegicus CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity ADP + phosphorylated protein CREB
-
 ?
2.7.11.17 additional information Rattus norvegicus N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 neuron
-
 Rattus norvegicus
-
2.7.11.17 retina
-
 Rattus norvegicus
-
2.7.11.17 retinal ganglion cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + protein CREB CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity Rattus norvegicus ADP + phosphorylated protein CREB
-
 ?
2.7.11.17 ATP + protein CREB i.e. cyclic AMP-response element binding protein Rattus norvegicus ADP + phosphorylated protein CREB
-
 ?
2.7.11.17 additional information N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus