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Literature summary extracted from

  • Martyniuk, C.J.; Awad, R.; Hurley, R.; Finger, T.E.; Trudeau, V.L.
    Glutamic acid decarboxylase 65, 67, and GABA-transaminase mRNA expression and total enzyme activity in the goldfish (Carassius auratus) brain (2007), Brain Res., 1147, 154-166.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Carassius auratus
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-
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2.6.1.19 Carassius auratus Q2PZI2 fragment
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4.1.1.15 Carassius auratus
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
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 Carassius auratus
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2.6.1.19 brain transcripts of gamma-aminobutanoate transaminase and glutamic acid decarboxylase 65, and glutamic acid decarboxylase 67 are detected throughout the brain, largely in the ventral and medial regions of telencephalon, nucleus preopticus, nucleus recessus lateralis of the hypothalamus, and Purkinje cell layer of the cerebellum. Enzyme activity of gamma-aminobutanoate transaminase is highest in the hypothalamus and optic textum. Gamma-aminobutanoate transaminase activity is significantly higher than total glutamic acid decarboxylase activity Carassius auratus
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2.6.1.19 hypothalamus
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 Carassius auratus
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2.6.1.19 hypothalamus enzyme activity of gamma-aminobutanoate transaminase is highest in the hypothalamus and optic textum Carassius auratus
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2.6.1.19 nucleus preopticus transcripts of gamma-aminobutanoate transaminase and glutamic acid decarboxylase 65, and glutamic acid decarboxylase 67 are detected throughout the brain, largely in the ventral and medial regions of telencephalon, nucleus preopticus, nucleus recessus lateralis of the hypothalamus, and Purkinje cell layer of the cerebellum Carassius auratus
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2.6.1.19 nucleus recessus lateralis transcripts of gamma-aminobutanoate transaminase and glutamic acid decarboxylase 65, and glutamic acid decarboxylase 67 are detected throughout the brain, largely in the ventral and medial regions of telencephalon, nucleus preopticus, nucleus recessus lateralis of the hypothalamus, and Purkinje cell layer of the cerebellum Carassius auratus
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2.6.1.19 optic tectum
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 Carassius auratus
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2.6.1.19 Purkinje cell transcripts of gamma-aminobutanoate transaminase and glutamic acid decarboxylase 65, and glutamic acid decarboxylase 67 are detected throughout the brain, largely in the ventral and medial regions of telencephalon, nucleus preopticus, nucleus recessus lateralis of the hypothalamus, and Purkinje cell layer of the cerebellum Carassius auratus
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2.6.1.19 tectum mesencephali enzyme activity of gamma-aminobutanoate transaminase is highest in the hypothalamus and optic tectum Carassius auratus
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2.6.1.19 telencephalon transcripts of gamma-aminobutanoate transaminase and glutamic acid decarboxylase 65, and glutamic acid decarboxylase 67 are detected throughout the brain, largely in the ventral and medial regions of telencephalon, nucleus preopticus, nucleus recessus lateralis of the hypothalamus, and Purkinje cell layer of the cerebellum Carassius auratus
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4.1.1.15 brain enzyme transcripts are detected largely in medial and ventral regions of telencephalon, nucleus preopticus, nucelus recessus lateralis of the hypothalamus, and Purkinje cell layer of the cerebellum. GABA-transamainase activity is significanlty higher than total glutamic acid decarboxylase activity in the brain Carassius auratus
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4.1.1.15 nucleus preopticus
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 Carassius auratus
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4.1.1.15 nucleus recessus lateralis of the hypothalamus, isoform GAD65 is significantly more abundant than isoform GAD67 Carassius auratus
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4.1.1.15 Purkinje cell
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 Carassius auratus
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4.1.1.15 telencephalon
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 Carassius auratus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
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 Carassius auratus 4-oxobutanoate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA transaminase
-
 Carassius auratus
2.6.1.19 GABA-T
-
 Carassius auratus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate 0.01 mM Carassius auratus