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Literature summary extracted from
- Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver (2007), Br. J. Nutr., 97, 58-66.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.13.8 | expression analysis of FMO3 in liver and after treatment with conjugated linoleic acid isomers | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | additional information | cis9, trans11-conjugated linoleic acid reduces expression of FMO3 by 61% | Mus musculus | |
| 1.14.13.8 | trans10, cis12-conjugated linoleic acid | reduces expression of FMO3 by 95%, and inhibits activity of hepatic microsomal FMO by 40% and of isozyme FMO3 activity by 67%, the compound has a strong effect on hepatic fatyy acid oxidation, overview | Mus musculus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.8 | microsome | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | additional information | Mus musculus | the enzyme is involved in fatty acid oxidation in the liver, as well as in drug detoxification | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | Mus musculus | - |
8-weeks-old female C57BL/6N mice | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | liver | expression analysis of FMO3 in liver and after treatment with conjugated linoleic acid isomers | Mus musculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | additional information | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | methyl 4-tolyl sulfide + NADPH + O2 | - |
Mus musculus | methyl 4-tolyl sulfoxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | additional information | the enzyme is involved in fatty acid oxidation in the liver, as well as in drug detoxification | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.8 | flavin monooxygenase | - |
Mus musculus |
| 1.14.13.8 | FMO | - |
Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 37 | - |
assay at | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 7.4 | 9.5 | assay at | Mus musculus |
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Release 2023.1 (January 2023)
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