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Literature summary extracted from

  • Akagi, R.; Inoue, R.; Muranaka, S.; Tahara, T.; Taketani, S.; Anderson, K.E.; Phillips, J.D.; Sassa, S.
    Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient (2006), Br. J. Haematol., 132, 237-243.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.3.3 medicine first patient with porphyria where both CPO and delta-aminolaevulinic acid dehydratase are deficient at the molecular level Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.3 mature form of wild-type CPOX cloned into pET-22, wild-type and mutant protein expressed in Escherichia coli BL21(DE3)plysS Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.3.3 G279R novel nucleotide transition found, is unstable, and produces ca. 2-5% of activity compared with the wild-type CPO Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Homo sapiens P36551 male patient with a typical attack of hepatic porphyria
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.3 by Ni2+ affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 coproporphyrinogen oxidase
-
 Homo sapiens
1.3.3.3 CPO
-
 Homo sapiens
1.3.3.3 CPOX
-
 Homo sapiens