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Literature summary extracted from

  • Geoerger, B.; Vassal, G.; Doz, F.; OQuigley, J.; Wartelle, M.; Watson, A.J.; Raquin, M.A.; Frappaz, D.; Chastagner, P.; Gentet, J.C.; Rubie, H.; Couanet, D.; Geoffray, A.; Djafari, L.; Margison, G.P.; Pein, F.
    Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies (2005), Br. J. Cancer, 93, 529-537.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.63 medicine combining cisplatin and temozolomide is based on the potential for improved antitumour activity, combination is well tolerated in children and adolescents, generating no toxicity greater than that of the single agents Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.63 temozolomide treatment for 5 days depletes MGMT in peripheral mononuclear cells in at least 76% of patients and low MGMT activity is correlated with severe thrombocytopenia during the first treatment cycle Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 PBMC cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
-
 Homo sapiens
2.1.1.63 O6-alkylguanine-DNA alkyltransferase
-
 Homo sapiens