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Literature summary extracted from

  • Fraccascia, P.; Sniekers, M.; Casteels, M.; Van Veldhoven, P.P.
    Presence of thiamine pyrophosphate in mammalian peroxisomes (2007), BMC Biochem., 8, 10.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.6.2 cytosol exclusively Rattus norvegicus 5829
-
2.7.6.2 cytosol exclusively Mus musculus 5829
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2.7.6.2 additional information no enzyme localization in the peroxisome, subcellular localization analysis, overview Rattus norvegicus
-
-
2.7.6.2 additional information no enzyme localization in the peroxisome, subcellular localization analysis, overview Mus musculus
-
-
2.7.6.2 peroxisome Peroxisomes are devoid of thiamine pyrophosphokinase activity. Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.2 ATP + thiamine Rattus norvegicus importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes AMP + thiamine diphosphate
-
 ?
2.7.6.2 ATP + thiamine Mus musculus importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes AMP + thiamine diphosphate
-
 ?
2.7.6.2 thiamine + ATP Rattus norvegicus TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase. thiamine diphosphate + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.2 Mus musculus Q59Q36
-
-
2.7.6.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.6.2 brain
-
 Rattus norvegicus
-
2.7.6.2 liver
-
 Rattus norvegicus
-
2.7.6.2 liver
-
 Mus musculus
-
2.7.6.2 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.2 ATP + thiamine
-
 Rattus norvegicus AMP + thiamine diphosphate
-
 ?
2.7.6.2 ATP + thiamine
-
 Mus musculus AMP + thiamine diphosphate
-
 ?
2.7.6.2 ATP + thiamine importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes Rattus norvegicus AMP + thiamine diphosphate
-
 ?
2.7.6.2 ATP + thiamine importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes Mus musculus AMP + thiamine diphosphate
-
 ?
2.7.6.2 thiamine + ATP TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase. Rattus norvegicus thiamine diphosphate + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.6.2 thiamine pyrophokinase
-
 Rattus norvegicus
2.7.6.2 thiamine pyrophosphokinase
-
 Rattus norvegicus
2.7.6.2 thiamine pyrophosphokinase
-
 Mus musculus
2.7.6.2 TPK
-
 Rattus norvegicus
2.7.6.2 TPK
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.6.2 ATP
-
 Rattus norvegicus
2.7.6.2 ATP
-
 Mus musculus