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Literature summary extracted from

  • Giordano, D.; Magaletti, D.M.; Clark, E.A.
    Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19 (2006), Blood, 107, 1537-1545.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 cGMP
-
 Homo sapiens
2.7.11.12 lipopolysaccharides induces enzyme expression and activates the enzyme Homo sapiens
2.7.11.12 NO
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 additional information the enzyme is regulated via negative feedback Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 ATP + vasodilator stimulated phosphoprotein Homo sapiens phosphorylation of vasodilator stimulated phosphoprotein, i.e. VASP, induces detachment of VASP and other cytoskeletal proteins from focal adhesion, phosphorylated VASP may prevent dendritic cells from migrating towards CCl19 ADP + phosphorylated vasodilator stimulated phosphoprotein
-
 ?
2.7.11.12 additional information Homo sapiens NO and cGMP protein kinase regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19, cGMP/cGK pathway, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 dendritic cell derived from CD14+ monocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + vasodilator stimulated phosphoprotein phosphorylation of vasodilator stimulated phosphoprotein, i.e. VASP, induces detachment of VASP and other cytoskeletal proteins from focal adhesion, phosphorylated VASP may prevent dendritic cells from migrating towards CCl19 Homo sapiens ADP + phosphorylated vasodilator stimulated phosphoprotein
-
 ?
2.7.11.12 ATP + vasodilator stimulated phosphoprotein phosphorylation at Ser239 Homo sapiens ADP + phosphorylated vasodilator stimulated phosphoprotein
-
 ?
2.7.11.12 additional information NO and cGMP protein kinase regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19, cGMP/cGK pathway, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 CGK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
 Homo sapiens