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Literature summary extracted from

  • Abe, M.; Ozawa, Y.; Uda, Y.; Morimitsu, Y.; Nakamura, Y.; Osawa, T.
    A novel labdane-type trialdehyde from myoga (Zingiber mioga Roscoe) that potently inhibits human platelet aggregation and human 5-lipoxygenase (2006), Biosci. Biotechnol. Biochem., 70, 2494-2500.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 miogadial potent inhibitor, IC50: 0.004 mM Homo sapiens
1.13.11.34 miogatrial potent inhibitor, IC50: 0.0075 mM Homo sapiens
1.13.11.34 additional information no inhibition by galanal A, galanal B and 8beta(17)-epoxy-15-hydroxy-12(E)-labden-16-al Homo sapiens
1.13.11.34 polygodial strong inhibitory activity, IC50: 0.0086 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-LOX
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.004
-
 potent inhibitor, IC50: 0.004 mM Homo sapiens miogadial
1.13.11.34 0.0075
-
 potent inhibitor, IC50: 0.0075 mM Homo sapiens miogatrial
1.13.11.34 0.0086
-
 strong inhibitory activity, IC50: 0.0086 mM Homo sapiens polygodial