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Literature summary extracted from

  • Yuan, H.; Silverman, R.B.
    Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase (2007), Bioorg. Med. Chem. Lett., 17, 1651-1654.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid potent irreversible inhibitor Homo sapiens
2.6.1.19 (1S,4S)-2-(difluoromethylidene)-4-(1H-tetrazol-5-yl)cyclopentanamine time-dependent inactivation, ratio kinact/KI value at pH 8.0 is 2.48 per min and mM Homo sapiens
2.6.1.19 S-vigabatrin ratio kinact/KI is1.7 per min and mM at pH 8.5, 0.11per min and mM at pH 6.5, respectively Homo sapiens
2.6.1.19 vigabatrin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Homo sapiens 4-oxobutanoate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA aminotransferase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.19 8
-
-
 Homo sapiens
2.6.1.19 8.5
-
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.19 3.75
-
 (1S,4S)-2-(difluoromethylidene)-4-(1H-tetrazol-5-yl)cyclopentanamine pH 6.5 Homo sapiens