Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chimenti, F.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Carradori, S.; Befani, O.; Turini, P.; Alcaro, S.; Ortuso, F.
    Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of N,N-bis[2-oxo-2H-benzopyran]-3-carboxamides (2006), Bioorg. Med. Chem. Lett., 16, 4135-4140.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 additional information both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes; both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes Homo sapiens
1.4.3.4 N,N'-(1R,2S)-cyclohexane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
 Bos taurus
1.4.3.4 N,N'-1,2-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
 Bos taurus
1.4.3.4 N,N'-1,4-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
 Bos taurus
1.4.3.4 N,N'-butane-1,4-diylbis(2-oxo-2H-chromene-3-carboxamide) potent inhibitor of MAO-A with high selectivity towards MAO-B; potent inhibitor of MAO-A with high selectivity towards MAO-B Bos taurus
1.4.3.4 N,N'-butane-1,4-diylbis(7-methoxy-2-oxo-2H-chromene-3-carboxamide)
-
 Bos taurus
1.4.3.4 N,N'-ethane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
 Bos taurus
1.4.3.4 N,N'-hexane-1,6-diylbis(2-oxo-2H-chromene-3-carboxamide) potent inhibitor of MAO-A with high selectivity towards MAO-B; potent inhibitor of MAO-A with high selectivity towards MAO-B Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus P21398
-
-
1.4.3.4 Bos taurus P56560
-
-
1.4.3.4 Homo sapiens P21397
-
-
1.4.3.4 Homo sapiens P27338
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO A
-
 Homo sapiens
1.4.3.4 MAO A
-
 Bos taurus
1.4.3.4 MAO B
-
 Homo sapiens
1.4.3.4 MAO B
-
 Bos taurus