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Literature summary extracted from

  • Zeng, J.; Deng, G.; Yu, W.; Li, D.
    Inactivation of medium-chain acyl-CoA dehydrogenase by oct-4-en-2-ynoyl-CoA (2006), Bioorg. Med. Chem. Lett., 16, 1445-1448.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.8.7 medicine inhibitor may become a lead for further development for treating non-insulin-dependent diabetes mellitus Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.7 additional information not inhibited by trans-2,trans-4-octadienoyl-CoA and oct-2-en-4-ynoyl-CoA Rattus norvegicus
1.3.8.7 oct-4-en-2-ynoyl-CoA irreversible inhibitor, active-site directed, enzyme protected by 2-octenoyl-CoA Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.8.7 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.7
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.7 octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
-
 Rattus norvegicus 2-octenoyl-CoA + reduced acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.7 MCAD
-
 Rattus norvegicus
1.3.8.7 medium chain-specific acyl-CoA oxidase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.7 FAD is not the target of the inhibitor Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.8.7 0.011
-
 oct-4-en-2-ynoyl-CoA
-
 Rattus norvegicus