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Literature summary extracted from

  • Cali, P.; Naerum, L.; Mukhija, S.; Hjelmencrantz, A.
    Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents (2004), Bioorg. Med. Chem. Lett., 14, 5997-6000.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.88 medicine peptide deformylase represents a target for the discovery of broad spectrum antibacterial drugs Staphylococcus aureus
3.5.1.88 medicine peptide deformylase represents a target for the discovery of broad spectrum antibacterial drugs Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.88 actinonin
-
 Escherichia coli
3.5.1.88 actinonin
-
 Staphylococcus aureus
3.5.1.88 BB-83698
-
 Staphylococcus aureus
3.5.1.88 isoxazole-3-hydroxamic acids 23 different compounds were synthesized and compared to the inhibitory activity of actinonin Escherichia coli
3.5.1.88 isoxazole-3-hydroxamic acids 23 different compounds were synthesized and compared to the inhibitory activity of actinonin Staphylococcus aureus
3.5.1.88 reverse hydroxamate British Biotech BB-83698 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.88 formyl-L-methionyl peptide + H2O Staphylococcus aureus
-
 formate + methionyl peptide
-
 ?
3.5.1.88 formyl-L-methionyl peptide + H2O Escherichia coli
-
 formate + methionyl peptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.88 Escherichia coli P0A6K3
-
-
3.5.1.88 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.88 formyl-L-methionyl peptide + H2O
-
 Staphylococcus aureus formate + methionyl peptide
-
 ?
3.5.1.88 formyl-L-methionyl peptide + H2O
-
 Escherichia coli formate + methionyl peptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.88 PDF
-
 Staphylococcus aureus
3.5.1.88 PDF
-
 Escherichia coli
3.5.1.88 peptide deformylase
-
 Staphylococcus aureus
3.5.1.88 peptide deformylase
-
 Escherichia coli