Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Al-Rashood, S.T.; Aboldahab, I.A.; Nagi, M.N.; Abouzeid, L.A.; Abdel-Aziz, A.A.; Abdel-Hamide, S.G.; Youssef, K.M.; Al-Obaid, A.M.; El-Subbagh, H.I.
    Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs (2006), Bioorg. Med. Chem., 14, 8608-8621.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 3-benzyl-6-[(3,4-dimethoxybenzyl)(methyl)amino]-2-(methylsulfanyl)quinazolin-4(3H)-one 50% inhibition at 0.001 mM Bos taurus
1.5.1.3 3-benzyl-6-[(4-methoxybenzyl)(methyl)amino]-2-(methylsulfanyl)quinazolin-4(3H)-one 50% inhibition at 0.0005 mM Bos taurus
1.5.1.3 4-benzyl-N-[3-benzyl-2-(methylsulfanyl)-4-oxo-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 50% inhibition at 0.008 mM Bos taurus
1.5.1.3 4-bromo-N-[2-(methylthio)-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 50% inhibition at 0.002 mM Bos taurus
1.5.1.3 6-([(1E)-(4-methoxyphenyl)methylene]amino)-2-(methylthio)-3-phenylquinazolin-4(3H)-one 50% inhibition at 0.002 mM Bos taurus
1.5.1.3 6-[(4-methoxybenzyl)(methyl)amino]-2-(methylsulfanyl)-3-phenylquinazolin-4(3H)-one 50% inhibition at 0.001 mM Bos taurus
1.5.1.3 N-[2-(methylsulfanyl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl]biphenyl-4-sulfonamide 50% inhibition at 0.005 mM Bos taurus
1.5.1.3 N-[2-(methylthio)-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 50% inhibition at 0.002 mM Bos taurus
1.5.1.3 N-[3-benzyl-2-(methylsulfanyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-4-methylbenzenesulfonamide 50% inhibition at 0.007 mM Bos taurus
1.5.1.3 N-[3-benzyl-2-(methylthio)-4-oxo-3,4-dihydroquinazolin-6-yl]-4-bromobenzenesulfonamide 50% inhibition at 0.005 mM Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.3 liver
-
 Bos taurus
-