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Literature summary extracted from

  • Castilho, M.S.; Postigo, M.P.; de Paula, C.B.; Montanari, C.A.; Oliva, G.; Andricopulo, A.D.
    Two- and three-dimensional quantitative structure-activity relationships for a series of purine nucleoside phosphorylase inhibitors (2006), Bioorg. Med. Chem., 14, 516-527.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.1 (3S)-3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chlorophenyl)propanoic acid IC50: 0.000036 mM Bos taurus
2.4.2.1 2,6-diamino-7-(5-mercapto-3,3-dimethylpentyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00005 mM Bos taurus
2.4.2.1 2,6-diamino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.0066 mM Bos taurus
2.4.2.1 2,8-diamino-1,7-dihydro-6H-purine-6-thione IC50: 0.00849 mM Bos taurus
2.4.2.1 2,8-diamino-1,9-dihydro-6H-purin-6-one IC50: 0.002299 mM Bos taurus
2.4.2.1 2,8-diamino-3-(2-thienylmethyl)-3,9-dihydro-6H-purin-6-one IC50: 0.001758 mM Bos taurus
2.4.2.1 2,8-diamino-9-(1,3-thiazol-4-ylmethyl)-1,9-dihydro-6H-purin-6-one IC50: 0.001043 mM Bos taurus
2.4.2.1 2,8-diamino-9-(2-furylmethyl)-1,9-dihydro-6H-purin-6-one IC50: 0.000092 mM; IC50: 0.00271 mM Bos taurus
2.4.2.1 2,8-diamino-9-(2-thienylmethyl)-1,9-dihydro-6H-purin-6-one IC50: 0.000497 mM Bos taurus
2.4.2.1 2,8-diamino-9-(4-fluorobenzyl)-1,9-dihydro-6H-purin-6-one IC50: 0.00417 mM Bos taurus
2.4.2.1 2,8-diamino-9-(pyridin-2-ylmethyl)-1,9-dihydro-6H-purin-6-one IC50: 0.001971 mM Bos taurus
2.4.2.1 2,8-diamino-9-[(4-methyl-2-thienyl)methyl]-1,9-dihydro-6H-purin-6-one IC50: 0.000362 mM Bos taurus
2.4.2.1 2,8-diamino-9-[4-(1H-imidazol-1-yl)benzyl]-1,9-dihydro-6H-purin-6-one IC50: 0.000852 mM Bos taurus
2.4.2.1 2,8-diamino-9-[[1-(heptyloxy)-2-hydroxyethoxy]methyl]-1,9-dihydro-6H-purin-6-one IC50: 0.00152 mM Bos taurus
2.4.2.1 2-(3,4-dichlorophenyl)-5-thioxo-5,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3,7(2H,4H)-dione IC50: 0.00703 mM Bos taurus
2.4.2.1 2-amino-7-(1,2-dithian-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000018 mM Bos taurus
2.4.2.1 2-amino-7-(2,3,5-trichlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00024 mM Bos taurus
2.4.2.1 2-amino-7-(2-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00012 mM Bos taurus
2.4.2.1 2-amino-7-(2-furylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000083 mM Bos taurus
2.4.2.1 2-amino-7-(2-hydroxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00027 mM Bos taurus
2.4.2.1 2-amino-7-(2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000021 mM Bos taurus
2.4.2.1 2-amino-7-(2-thienylmethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one IC50: 0.000674 mM Bos taurus
2.4.2.1 2-amino-7-(3,4-dichlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000017 mM Bos taurus
2.4.2.1 2-amino-7-(3-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00002 mM Bos taurus
2.4.2.1 2-amino-7-(3-fluorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000024 mM Bos taurus
2.4.2.1 2-amino-7-(3-hydroxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00007 mM Bos taurus
2.4.2.1 2-amino-7-(3-methoxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000082 mM Bos taurus
2.4.2.1 2-amino-7-(3-methylbenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000057mM Bos taurus
2.4.2.1 2-amino-7-(3-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000025 mM Bos taurus
2.4.2.1 2-amino-7-(4-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000025 mM Bos taurus
2.4.2.1 2-amino-7-(4-iodobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000023 mM Bos taurus
2.4.2.1 2-amino-7-(biphenyl-4-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000546 mM Bos taurus
2.4.2.1 2-amino-7-(cycloheptylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00003 mM Bos taurus
2.4.2.1 2-amino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000047 mM Bos taurus
2.4.2.1 2-amino-7-(cyclopentylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000029 mM Bos taurus
2.4.2.1 2-amino-7-(piperidin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.001 mM Bos taurus
2.4.2.1 2-amino-7-(pyridin-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000015 mM Bos taurus
2.4.2.1 2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000025 mM Bos taurus
2.4.2.1 2-amino-7-(pyridin-4-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000064 mM Bos taurus
2.4.2.1 2-amino-7-(tetrahydro-2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000011 mM Bos taurus
2.4.2.1 2-amino-7-(tetrahydrofuran-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00007 mM Bos taurus
2.4.2.1 2-amino-7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000051 mM Bos taurus
2.4.2.1 2-amino-7-cyclohex-1-en-1-yl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.0019 mM Bos taurus
2.4.2.1 2-amino-7-phenoxy-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000042 mM Bos taurus
2.4.2.1 2-amino-7-[(3-methylcyclohexyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000025 mM Bos taurus
2.4.2.1 2-amino-7-[(3-tert-butylcyclohexyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000025 mM Bos taurus
2.4.2.1 2-amino-7-[(4-chloropyridin-3-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000135 mM Bos taurus
2.4.2.1 2-amino-7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000124 mM; IC50: 0.000147 mM Bos taurus
2.4.2.1 2-amino-7-[3-(trifluoromethyl)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000036 mM Bos taurus
2.4.2.1 2-amino-7-[[(1R,3S,5S,7S)-4-methyl-2-adamantyl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00009 mM Bos taurus
2.4.2.1 2-amino-9-(2-thienylmethyl)-8-thioxo-1,7,8,9-tetrahydro-6H-purin-6-one IC50: 0.002866 mM Bos taurus
2.4.2.1 2-phenyl-5,7-dithioxo-1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-d]pyrimidin-3-one IC50: 0.02284 mM Bos taurus
2.4.2.1 3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenylpropanoic acid IC50: 0.000047 mM Bos taurus
2.4.2.1 3-(3-chlorophenyl)-3-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)propanenitrile IC50: 0.000011 mM Bos taurus
2.4.2.1 3-(3-chlorophenyl)-3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)propanenitrile IC50: 0.00001 mM Bos taurus
2.4.2.1 3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-pyridin-3-ylpropanenitrile IC50: 0.000039 mM Bos taurus
2.4.2.1 5-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,3-dimethylpentane-1-sulfonamide IC50: 0.0001 mM Bos taurus
2.4.2.1 5-amino-3-(2-thienylmethyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one IC50: 0.001839 mM Bos taurus
2.4.2.1 6-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-4,4-dimethylhexanamide IC50: 0.2 mM Bos taurus
2.4.2.1 6-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-4,4-dimethylhexanenitrile IC50: 0.00026 mM Bos taurus
2.4.2.1 6-amino-7-(2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00016 mM Bos taurus
2.4.2.1 7-(3-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000028 mM Bos taurus
2.4.2.1 7-(cyclopentylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000029 mM Bos taurus
2.4.2.1 7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00004 mM Bos taurus
2.4.2.1 7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.000035 mM Bos taurus
2.4.2.1 7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one IC50: 0.00019 mM Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.1 Bos taurus P55859 calf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.1 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.1 inosine + phosphate
-
 Bos taurus hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.1 0.00001
-
 IC50: 0.00001 mM Bos taurus 3-(3-chlorophenyl)-3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)propanenitrile
2.4.2.1 0.000011
-
 IC50: 0.000011 mM Bos taurus 2-amino-7-(tetrahydro-2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000011
-
 IC50: 0.000011 mM Bos taurus 3-(3-chlorophenyl)-3-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)propanenitrile
2.4.2.1 0.000015
-
 IC50: 0.000015 mM Bos taurus 2-amino-7-(pyridin-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000017
-
 IC50: 0.000017 mM Bos taurus 2-amino-7-(3,4-dichlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000018
-
 IC50: 0.000018 mM Bos taurus 2-amino-7-(1,2-dithian-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00002
-
 IC50: 0.00002 mM Bos taurus 2-amino-7-(3-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000021
-
 IC50: 0.000021 mM Bos taurus 2-amino-7-(2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000023
-
 IC50: 0.000023 mM Bos taurus 2-amino-7-(4-iodobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000024
-
 IC50: 0.000024 mM Bos taurus 2-amino-7-(3-fluorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000025
-
 IC50: 0.000025 mM Bos taurus 2-amino-7-(3-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000025
-
 IC50: 0.000025 mM Bos taurus 2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000025
-
 IC50: 0.000025 mM Bos taurus 2-amino-7-[(3-tert-butylcyclohexyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000025
-
 IC50: 0.000025 mM Bos taurus 2-amino-7-(4-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000025
-
 IC50: 0.000025 mM Bos taurus 2-amino-7-[(3-methylcyclohexyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000028
-
 IC50: 0.000028 mM Bos taurus 7-(3-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000029
-
 IC50: 0.000029 mM Bos taurus 2-amino-7-(cyclopentylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000029
-
 IC50: 0.000029 mM Bos taurus 7-(cyclopentylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00003
-
 IC50: 0.00003 mM Bos taurus 2-amino-7-(cycloheptylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000035
-
 IC50: 0.000035 mM Bos taurus 7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000036
-
 IC50: 0.000036 mM Bos taurus 2-amino-7-[3-(trifluoromethyl)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000036
-
 IC50: 0.000036 mM Bos taurus (3S)-3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chlorophenyl)propanoic acid
2.4.2.1 0.000039
-
 IC50: 0.000039 mM Bos taurus 3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-pyridin-3-ylpropanenitrile
2.4.2.1 0.00004
-
 IC50: 0.00004 mM Bos taurus 7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000042
-
 IC50: 0.000042 mM Bos taurus 2-amino-7-phenoxy-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000047
-
 IC50: 0.000047 mM Bos taurus 2-amino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000047
-
 IC50: 0.000047 mM Bos taurus 3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenylpropanoic acid
2.4.2.1 0.00005
-
 IC50: 0.00005 mM Bos taurus 2,6-diamino-7-(5-mercapto-3,3-dimethylpentyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000051
-
 IC50: 0.000051 mM Bos taurus 2-amino-7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000057
-
 IC50: 0.000057mM Bos taurus 2-amino-7-(3-methylbenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000064
-
 IC50: 0.000064 mM Bos taurus 2-amino-7-(pyridin-4-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00007
-
 IC50: 0.00007 mM Bos taurus 2-amino-7-(tetrahydrofuran-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00007
-
 IC50: 0.00007 mM Bos taurus 2-amino-7-(3-hydroxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000082
-
 IC50: 0.000082 mM Bos taurus 2-amino-7-(3-methoxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000083
-
 IC50: 0.000083 mM Bos taurus 2-amino-7-(2-furylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00009
-
 IC50: 0.00009 mM Bos taurus 2-amino-7-[[(1R,3S,5S,7S)-4-methyl-2-adamantyl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000092
-
 IC50: 0.000092 mM Bos taurus 2,8-diamino-9-(2-furylmethyl)-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.0001
-
 IC50: 0.0001 mM Bos taurus 5-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,3-dimethylpentane-1-sulfonamide
2.4.2.1 0.00012
-
 IC50: 0.00012 mM Bos taurus 2-amino-7-(2-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000124
-
 IC50: 0.000124 mM Bos taurus 2-amino-7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000135
-
 IC50: 0.000135 mM Bos taurus 2-amino-7-[(4-chloropyridin-3-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000147
-
 IC50: 0.000147 mM Bos taurus 2-amino-7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00016
-
 IC50: 0.00016 mM Bos taurus 6-amino-7-(2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00019
-
 IC50: 0.00019 mM Bos taurus 7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00024
-
 IC50: 0.00024 mM Bos taurus 2-amino-7-(2,3,5-trichlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00026
-
 IC50: 0.00026 mM Bos taurus 6-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-4,4-dimethylhexanenitrile
2.4.2.1 0.00027
-
 IC50: 0.00027 mM Bos taurus 2-amino-7-(2-hydroxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000362
-
 IC50: 0.000362 mM Bos taurus 2,8-diamino-9-[(4-methyl-2-thienyl)methyl]-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.000497
-
 IC50: 0.000497 mM Bos taurus 2,8-diamino-9-(2-thienylmethyl)-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.000546
-
 IC50: 0.000546 mM Bos taurus 2-amino-7-(biphenyl-4-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.000674
-
 IC50: 0.000674 mM Bos taurus 2-amino-7-(2-thienylmethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
2.4.2.1 0.000852
-
 IC50: 0.000852 mM Bos taurus 2,8-diamino-9-[4-(1H-imidazol-1-yl)benzyl]-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.001
-
 IC50: 0.001 mM Bos taurus 2-amino-7-(piperidin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.001043
-
 IC50: 0.001043 mM Bos taurus 2,8-diamino-9-(1,3-thiazol-4-ylmethyl)-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.00152
-
 IC50: 0.00152 mM Bos taurus 2,8-diamino-9-[[1-(heptyloxy)-2-hydroxyethoxy]methyl]-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.001758
-
 IC50: 0.001758 mM Bos taurus 2,8-diamino-3-(2-thienylmethyl)-3,9-dihydro-6H-purin-6-one
2.4.2.1 0.001839
-
 IC50: 0.001839 mM Bos taurus 5-amino-3-(2-thienylmethyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
2.4.2.1 0.0019
-
 IC50: 0.0019 mM Bos taurus 2-amino-7-cyclohex-1-en-1-yl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.001971
-
 IC50: 0.001971 mM Bos taurus 2,8-diamino-9-(pyridin-2-ylmethyl)-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.002299
-
 IC50: 0.002299 mM Bos taurus 2,8-diamino-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.00271
-
 IC50: 0.00271 mM Bos taurus 2,8-diamino-9-(2-furylmethyl)-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.002866
-
 IC50: 0.002866 mM Bos taurus 2-amino-9-(2-thienylmethyl)-8-thioxo-1,7,8,9-tetrahydro-6H-purin-6-one
2.4.2.1 0.00417
-
 IC50: 0.00417 mM Bos taurus 2,8-diamino-9-(4-fluorobenzyl)-1,9-dihydro-6H-purin-6-one
2.4.2.1 0.0066
-
 IC50: 0.0066 mM Bos taurus 2,6-diamino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2.4.2.1 0.00703
-
 IC50: 0.00703 mM Bos taurus 2-(3,4-dichlorophenyl)-5-thioxo-5,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3,7(2H,4H)-dione
2.4.2.1 0.00849
-
 IC50: 0.00849 mM Bos taurus 2,8-diamino-1,7-dihydro-6H-purine-6-thione
2.4.2.1 0.02284
-
 IC50: 0.02284 mM Bos taurus 2-phenyl-5,7-dithioxo-1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-d]pyrimidin-3-one
2.4.2.1 0.2
-
 IC50: 0.2 mM Bos taurus 6-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-4,4-dimethylhexanamide