EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.5.1.15 | more putative structural model of five mutations in DHPS to explain sulfadoxine resistance, structural model based on crystal structures of Saccharomyces cerevisiae (PPPK-DHPS), Mycobacterium tuberculosis (DHPS), Bacillus anthracis (DHPS), and Escherichia coli (PPPK) | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.15 | sulfadoxine | - |
Plasmodium falciparum |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.3 | Mg2+ | - |
Plasmodium falciparum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.15 | 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | Plasmodium falciparum | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
2.7.6.3 | 6-hydroxymethyl-7,8-dihydropterin + ATP | Plasmodium falciparum | - |
6-hydroxymethyl-7,8-dihydropterin diphosphate + AMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.15 | Plasmodium falciparum | Q27735 | fragment of dihydropteroate synthase | - |
2.7.6.3 | Plasmodium falciparum | Q27865 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.15 | 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Plasmodium falciparum | diphosphate + 7,8-dihydropteroate | - |
? | |
2.7.6.3 | 6-hydroxymethyl-7,8-dihydropterin + ATP | - |
Plasmodium falciparum | 6-hydroxymethyl-7,8-dihydropterin diphosphate + AMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.15 | 7,8-dihydropteroate synthase | - |
Plasmodium falciparum |
2.5.1.15 | DHPS | - |
Plasmodium falciparum |
2.5.1.15 | dihydropteroate synthetase | - |
Plasmodium falciparum |
2.7.6.3 | dihydropterin pyrophosphokinase | - |
Plasmodium falciparum |