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Literature summary extracted from

  • Khan, K.M.; Maharvi, G.M.; Khan, M.T.H.; Shaikh, A.J.; Perveen, S.; Begum, S.; Choudhary, M.I.
    Tetraketones: a new class of tyrosinase inhibitors (2006), Bioorg. Med. Chem., 14, 344-351.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.1 3-aminophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione) IC50: 0.0021 mM Agaricus bisporus
1.10.3.1 3-aminophenyl-2,2'-methylenebis-(cyclohexane-1,3-dione) IC50: 0.00219 mM Agaricus bisporus
1.10.3.1 3-chlorophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione) IC50: 0.0032 mM Agaricus bisporus
1.10.3.1 kojic acid IC50: 0.016.67 mM Agaricus bisporus
1.10.3.1 L-mimosine IC50: 0.00368 mM Agaricus bisporus
1.10.3.1 additional information synthesis and evaluation of several tetraketones with variable substituents at C-7, IC50 values, overview Agaricus bisporus
1.10.3.1 phenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione) IC50: 0.0026 mM Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.3.1 commercial preparation
-
 Agaricus bisporus
-

Synonyms

EC Number Synonyms Comment Organism
1.10.3.1 More cf. 1.14.18.1 Agaricus bisporus
1.10.3.1 polyphenol oxidase
-
 Agaricus bisporus
1.10.3.1 PPO
-
 Agaricus bisporus
1.10.3.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.3.1 0.0021
-
 IC50: 0.0021 mM Agaricus bisporus 3-aminophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
1.10.3.1 0.00219
-
 IC50: 0.00219 mM Agaricus bisporus 3-aminophenyl-2,2'-methylenebis-(cyclohexane-1,3-dione)
1.10.3.1 0.0026
-
 IC50: 0.0026 mM Agaricus bisporus phenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
1.10.3.1 0.0032
-
 IC50: 0.0032 mM Agaricus bisporus 3-chlorophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
1.10.3.1 0.00368
-
 IC50: 0.00368 mM Agaricus bisporus L-mimosine
1.10.3.1 0.016
-
 IC50: 0.016.67 mM Agaricus bisporus kojic acid