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Literature summary extracted from

  • Jao, S.C.; Chen, J.; Yang, K.; Li, W.S.
    Design of potent inhibitors for Schistosoma japonica glutathione S-transferase (2006), Bioorg. Med. Chem., 14, 304-318.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.18 expression of His-tagged enzyme in Escherichia coli Schistosoma japonicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 (17-chloro-3b-hydroxy-androsta-5,16-diene)-succinyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 (S)-2-amino-4-cyanobutyric acid
-
 Schistosoma japonicum
2.5.1.18 epiandrosterone-aspartyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 epiandrosterone-succinyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 gamma-glutamyl-(c-methoxycarbonyl)-alpha-glutamylglycine
-
 Schistosoma japonicum
2.5.1.18 gamma-glutamyl-5-azanylidyne-L-norvalylglycine
-
 Schistosoma japonicum
2.5.1.18 gamma-glutamyl-L-threonylglycine
-
 Schistosoma japonicum
2.5.1.18 gamma-L-glutamyl-L-seryl-glycine
-
 Schistosoma japonicum
2.5.1.18 additional information implementation of both structure-based drug design and the concept of polyvalency to discover a series of potent and unsymmetrical GST inhibitors, stoichiometry of one inhibitor molecule per GST monomer via isothermal titration calorimetric measurement, overview, molecular modeling Schistosoma japonicum
2.5.1.18 N5-[(1S)-2-[(carboxymethyl)amino]-1-(cyanomethyl)-2-oxoethyl]glutamine
-
 Schistosoma japonicum
2.5.1.18 prasterone-aspartyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 prasterone-succinyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 [(3aR,5R,7aR)-3a,5-dihydroxy-7a-methyloctahydro-1H-inden-1-one]-succinyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 [(3aR,5S,7aR)-3a,5-dihydroxy-7a-methyloctahydro-1H-inden-1-one]-aspartyl-glutathione
-
 Schistosoma japonicum
2.5.1.18 [(3aR,5S,7aR)-3a,5-dihydroxy-7a-methyloctahydro-1H-inden-1-one]-succinyl-glutathione
-
 Schistosoma japonicum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Schistosoma japonicum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18 recombinant His-tagged enzyme from Escherichia coli by nickel affinity chromatography Schistosoma japonicum

Synonyms

EC Number Synonyms Comment Organism
2.5.1.18 glutathione S-transferase
-
 Schistosoma japonicum
2.5.1.18 GST
-
 Schistosoma japonicum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.18 30
-
 assay at Schistosoma japonicum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.18 6.5
-
 assay at Schistosoma japonicum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.18 0.147
-
 pH 6.5, 30°C Schistosoma japonicum N5-[(1S)-2-[(carboxymethyl)amino]-1-(cyanomethyl)-2-oxoethyl]glutamine
2.5.1.18 0.395
-
 pH 6.5, 30°C Schistosoma japonicum (S)-2-amino-4-cyanobutyric acid
2.5.1.18 0.774
-
 pH 6.5, 30°C Schistosoma japonicum gamma-glutamyl-(c-methoxycarbonyl)-alpha-glutamylglycine
2.5.1.18 1.5
-
 above, pH 6.5, 30°C Schistosoma japonicum gamma-glutamyl-L-threonylglycine
2.5.1.18 3
-
 above, pH 6.5, 30°C Schistosoma japonicum gamma-glutamyl-5-azanylidyne-L-norvalylglycine